Structural basis for the coevolution of a viral RNA-protein complex

Jeffrey A. Chao, Yury Patskovsky, Steven C. Almo, Robert H. Singer

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved β-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalNature Structural and Molecular Biology
Volume15
Issue number1
DOIs
StatePublished - Jan 2008

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Viral RNA
Capsid Proteins
Viral Proteins
RNA
Molecular Structure
Bacteriophages

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

Cite this

Structural basis for the coevolution of a viral RNA-protein complex. / Chao, Jeffrey A.; Patskovsky, Yury; Almo, Steven C.; Singer, Robert H.

In: Nature Structural and Molecular Biology, Vol. 15, No. 1, 01.2008, p. 103-105.

Research output: Contribution to journalArticle

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