Striatal volume on magnetic resonance imaging and repetitive behaviors in autism

Eric Hollander, Evdokia Anagnostou, William Chaplin, Katherine Esposito, M. Mehmet Haznedar, Elizabeth Licalzi, Stacey Wasserman, Latha Soorya, Monte Buchsbaum

Research output: Contribution to journalArticle

228 Citations (Scopus)

Abstract

Background: The repetitive behaviors seen in autism phenotypically resemble those seen in obsessive-compulsive disorder (OCD) and Tourette Syndrome (TS), disorders in which structural and functional abnormalities of the basal ganglia (BG) are present and correspond to the severity of repetitive behaviors. Methods: Seventeen subjects with autism by DSM-IV and Autism Diagnostic Interview (ADI) and 17 matched controls completed a 1.5 T magnetic resonance image (MRI) of the brain. Two blinded researchers, with good inter-rater reliability, outlined the right and left caudate and putamen. Autistic and control BG volumes covaried for total brain volume were compared using analysis of covariance. BG volumes within the autistic group were correlated with the ADI Repetitive Behavior scores (ADI-C domain). Results: Right caudate volume controlled for total brain volume was significantly larger in autistic subjects than in controls. In addition, right caudate and total putamen volumes correlated positively with repetitive behavior scores on the ADI-C domain, particularly the higher order OCD-like repetitive behaviors. Conclusions: Increased right caudate volume in autism is of interest, since this has also been observed in OCD patients. Increased volume of the right caudate and total putamen positively correlated with greater repetitive behaviors, supporting the hypothesis of BG dysfunction associated with repetitive behaviors in autistic adults.

Original languageEnglish (US)
Pages (from-to)226-232
Number of pages7
JournalBiological Psychiatry
Volume58
Issue number3
DOIs
StatePublished - Aug 1 2005
Externally publishedYes

Fingerprint

Corpus Striatum
Autistic Disorder
Magnetic Resonance Imaging
Basal Ganglia
Putamen
Obsessive-Compulsive Disorder
Interviews
Tourette Syndrome
Brain
Diagnostic and Statistical Manual of Mental Disorders
Magnetic Resonance Spectroscopy
Research Personnel

Keywords

  • Autism
  • Basal ganglia
  • Repetitive behaviors

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Hollander, E., Anagnostou, E., Chaplin, W., Esposito, K., Haznedar, M. M., Licalzi, E., ... Buchsbaum, M. (2005). Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. Biological Psychiatry, 58(3), 226-232. https://doi.org/10.1016/j.biopsych.2005.03.040

Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. / Hollander, Eric; Anagnostou, Evdokia; Chaplin, William; Esposito, Katherine; Haznedar, M. Mehmet; Licalzi, Elizabeth; Wasserman, Stacey; Soorya, Latha; Buchsbaum, Monte.

In: Biological Psychiatry, Vol. 58, No. 3, 01.08.2005, p. 226-232.

Research output: Contribution to journalArticle

Hollander, E, Anagnostou, E, Chaplin, W, Esposito, K, Haznedar, MM, Licalzi, E, Wasserman, S, Soorya, L & Buchsbaum, M 2005, 'Striatal volume on magnetic resonance imaging and repetitive behaviors in autism', Biological Psychiatry, vol. 58, no. 3, pp. 226-232. https://doi.org/10.1016/j.biopsych.2005.03.040
Hollander, Eric ; Anagnostou, Evdokia ; Chaplin, William ; Esposito, Katherine ; Haznedar, M. Mehmet ; Licalzi, Elizabeth ; Wasserman, Stacey ; Soorya, Latha ; Buchsbaum, Monte. / Striatal volume on magnetic resonance imaging and repetitive behaviors in autism. In: Biological Psychiatry. 2005 ; Vol. 58, No. 3. pp. 226-232.
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