Strain-specific facilitation of dopamine efflux by Δ9-tetrahydrocannabinol in the nucleus accumbens of rat: An in vivo microdialysis study

Jianping Chen; William Paredes; Joyce H. Lowinson; Eliot L. Gardner

doi:10.1016/0304-3940(91)90739-G

Strain-specific facilitation of dopamine efflux by Δ⁹-tetrahydrocannabinol in the nucleus accumbens of rat: An in vivo microdialysis study

Jianping Chen, William Paredes, Joyce H. Lowinson, Eliot L. Gardner

Medicine

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

This study tests the hypothesis that Δ⁹-tetrahydrocannabinolΔ⁹-THC) has a strain-specific facilitatory effect on dopamine (DA) efflux in rat nucleus accumbens, a crucial forebrain convergence of reward-relevant DA neural fibers that has been implicated as a focal brain locus mediating the euphorigenic properties of drugs of abuse. The dependent variable is presynaptic DA efflux measured by in vivo microdialysis in the nucleus accumbens. The independent variables are: (1) intraperitoneal injections of Δ⁹-THC at 0.0 (vehicle), 0.5 and 1.0 mg/kg; (2) Sprague-Dawley vs Lewis strain rat. Results show that Δ⁹-THC produces a dose-dependent, strain-specific enhancement of basal DA efflux in Lewis strain rats. These results suggest that genetic variation influences drug abuse vulnerability.

Original language	English (US)
Pages (from-to)	136-140
Number of pages	5
Journal	Neuroscience Letters
Volume	129
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(91)90739-G
State	Published - Aug 5 1991

Keywords

Brain reward
Cannabis
Dopamine
Lewis rat
Marijuana
Microdialysis
Sprague-Dawley rat
Strain specificity
Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

General Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0304-3940(91)90739-G

Cite this

@article{704e9d2e899f45dda68e1205dc4ec29a,

title = "Strain-specific facilitation of dopamine efflux by Δ9-tetrahydrocannabinol in the nucleus accumbens of rat: An in vivo microdialysis study",

abstract = "This study tests the hypothesis that Δ9-tetrahydrocannabinolΔ9-THC) has a strain-specific facilitatory effect on dopamine (DA) efflux in rat nucleus accumbens, a crucial forebrain convergence of reward-relevant DA neural fibers that has been implicated as a focal brain locus mediating the euphorigenic properties of drugs of abuse. The dependent variable is presynaptic DA efflux measured by in vivo microdialysis in the nucleus accumbens. The independent variables are: (1) intraperitoneal injections of Δ9-THC at 0.0 (vehicle), 0.5 and 1.0 mg/kg; (2) Sprague-Dawley vs Lewis strain rat. Results show that Δ9-THC produces a dose-dependent, strain-specific enhancement of basal DA efflux in Lewis strain rats. These results suggest that genetic variation influences drug abuse vulnerability.",

keywords = "Brain reward, Cannabis, Dopamine, Lewis rat, Marijuana, Microdialysis, Sprague-Dawley rat, Strain specificity, Δ-Tetrahydrocannabinol",

author = "Jianping Chen and William Paredes and Lowinson, {Joyce H.} and Gardner, {Eliot L.}",

note = "Funding Information: This work was supported by National Institute on Drug Abuse research Grant DA 03622. J.C. was supported by funds from the Sue Golding Graduate Division of Medical Sciences, Albert Einstein College of Medicine. Ag-THC was supplied by the Research Technology Branch, National Institute on Drug Abuse. We are grateful to Drs. A.M. Etgen and H. Lachman for their helpful comments.",

year = "1991",

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AU - Chen, Jianping

AU - Paredes, William

AU - Lowinson, Joyce H.

AU - Gardner, Eliot L.

N1 - Funding Information: This work was supported by National Institute on Drug Abuse research Grant DA 03622. J.C. was supported by funds from the Sue Golding Graduate Division of Medical Sciences, Albert Einstein College of Medicine. Ag-THC was supplied by the Research Technology Branch, National Institute on Drug Abuse. We are grateful to Drs. A.M. Etgen and H. Lachman for their helpful comments.

PY - 1991/8/5

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N2 - This study tests the hypothesis that Δ9-tetrahydrocannabinolΔ9-THC) has a strain-specific facilitatory effect on dopamine (DA) efflux in rat nucleus accumbens, a crucial forebrain convergence of reward-relevant DA neural fibers that has been implicated as a focal brain locus mediating the euphorigenic properties of drugs of abuse. The dependent variable is presynaptic DA efflux measured by in vivo microdialysis in the nucleus accumbens. The independent variables are: (1) intraperitoneal injections of Δ9-THC at 0.0 (vehicle), 0.5 and 1.0 mg/kg; (2) Sprague-Dawley vs Lewis strain rat. Results show that Δ9-THC produces a dose-dependent, strain-specific enhancement of basal DA efflux in Lewis strain rats. These results suggest that genetic variation influences drug abuse vulnerability.

AB - This study tests the hypothesis that Δ9-tetrahydrocannabinolΔ9-THC) has a strain-specific facilitatory effect on dopamine (DA) efflux in rat nucleus accumbens, a crucial forebrain convergence of reward-relevant DA neural fibers that has been implicated as a focal brain locus mediating the euphorigenic properties of drugs of abuse. The dependent variable is presynaptic DA efflux measured by in vivo microdialysis in the nucleus accumbens. The independent variables are: (1) intraperitoneal injections of Δ9-THC at 0.0 (vehicle), 0.5 and 1.0 mg/kg; (2) Sprague-Dawley vs Lewis strain rat. Results show that Δ9-THC produces a dose-dependent, strain-specific enhancement of basal DA efflux in Lewis strain rats. These results suggest that genetic variation influences drug abuse vulnerability.

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