Strain-specific facilitation of dopamine efflux by Δ9-tetrahydrocannabinol in the nucleus accumbens of rat: An in vivo microdialysis study

Jianping Chen, William Paredes, Joyce H. Lowinson, Eliot L. Gardner

Research output: Contribution to journalArticle

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Abstract

This study tests the hypothesis that Δ9-tetrahydrocannabinolΔ9-THC) has a strain-specific facilitatory effect on dopamine (DA) efflux in rat nucleus accumbens, a crucial forebrain convergence of reward-relevant DA neural fibers that has been implicated as a focal brain locus mediating the euphorigenic properties of drugs of abuse. The dependent variable is presynaptic DA efflux measured by in vivo microdialysis in the nucleus accumbens. The independent variables are: (1) intraperitoneal injections of Δ9-THC at 0.0 (vehicle), 0.5 and 1.0 mg/kg; (2) Sprague-Dawley vs Lewis strain rat. Results show that Δ9-THC produces a dose-dependent, strain-specific enhancement of basal DA efflux in Lewis strain rats. These results suggest that genetic variation influences drug abuse vulnerability.

Original languageEnglish (US)
Pages (from-to)136-140
Number of pages5
JournalNeuroscience Letters
Volume129
Issue number1
DOIs
StatePublished - Aug 5 1991

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Keywords

  • Brain reward
  • Cannabis
  • Dopamine
  • Lewis rat
  • Marijuana
  • Microdialysis
  • Sprague-Dawley rat
  • Strain specificity
  • Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

  • Neuroscience(all)

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