Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Laura A. Herndon, Peter J. Schmeissner, Justyna M. Dudaronek, Paula A. Brown, Kristin M. Listner, Yuko Sakano, Marie C. Paupard, David H. Hall, Monica Driscoll

Research output: Contribution to journalArticle

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Abstract

The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity in different tissues as the animal ages. We report remarkable preservation of the nervous system, even in advanced old age, in contrast to a gradual, progressive deterioration of muscle, resembling human sarcopenia. The age-1(hx546) mutation, which extends lifespan by 60-100%, delayed some, but not all, cellular biomarkers of ageing. Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals.

Original languageEnglish (US)
Pages (from-to)808-814
Number of pages7
JournalNature
Volume419
Issue number6909
DOIs
StatePublished - Oct 24 2002

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Thromboplastin
Caenorhabditis elegans
Sarcopenia
Mutation
Cell Aging
Genetic Models
Life Expectancy
Green Fluorescent Proteins
Nervous System
Biomarkers
Genotype
Phenotype
Muscles

ASJC Scopus subject areas

  • General

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Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., ... Driscoll, M. (2002). Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature, 419(6909), 808-814. https://doi.org/10.1038/nature01135

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. / Herndon, Laura A.; Schmeissner, Peter J.; Dudaronek, Justyna M.; Brown, Paula A.; Listner, Kristin M.; Sakano, Yuko; Paupard, Marie C.; Hall, David H.; Driscoll, Monica.

In: Nature, Vol. 419, No. 6909, 24.10.2002, p. 808-814.

Research output: Contribution to journalArticle

Herndon, LA, Schmeissner, PJ, Dudaronek, JM, Brown, PA, Listner, KM, Sakano, Y, Paupard, MC, Hall, DH & Driscoll, M 2002, 'Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans', Nature, vol. 419, no. 6909, pp. 808-814. https://doi.org/10.1038/nature01135
Herndon LA, Schmeissner PJ, Dudaronek JM, Brown PA, Listner KM, Sakano Y et al. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature. 2002 Oct 24;419(6909):808-814. https://doi.org/10.1038/nature01135
Herndon, Laura A. ; Schmeissner, Peter J. ; Dudaronek, Justyna M. ; Brown, Paula A. ; Listner, Kristin M. ; Sakano, Yuko ; Paupard, Marie C. ; Hall, David H. ; Driscoll, Monica. / Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. In: Nature. 2002 ; Vol. 419, No. 6909. pp. 808-814.
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