Stimulation of immature male rat liver growth by phenobarbital and 3-methylcholanthrene

Leonard H. Augenlicht, Thomas S. Argyris

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Daily injections of 100 mg phenobarbital/kg body wt stimulate substantial increases in liver growth. However, after 5 days of treatment there is no further growth in response to phenobarbital. At this time, the liver still grows after a single injection of 20 mg of 3-methylcholanthrene/kg body wt. It is concluded that the two drugs stimulate liver growth by different mechanisms, as they do liver drug metabolizing enzyme activity. In addition, we have shown that 100 mg phenobarbital/kg body wt in the immature male rat stimulates liver growth by both hepatocyte hypertrophy and hyperplasia, while 20 mg 3-methylcholanthrene/kg body wt with or without phenobarbital pretreatment stimulates only cell hypertrophy. Neither drug significantly affects mitotic activity in littoral or bile duct cells.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalExperimental and Molecular Pathology
Volume22
Issue number1
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

Methylcholanthrene
Phenobarbital
Liver
Rats
Growth
Hypertrophy
Pharmaceutical Preparations
Injections
Enzyme activity
Bile Ducts
Ducts
Hyperplasia
Hepatocytes
Enzymes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

Cite this

Stimulation of immature male rat liver growth by phenobarbital and 3-methylcholanthrene. / Augenlicht, Leonard H.; Argyris, Thomas S.

In: Experimental and Molecular Pathology, Vol. 22, No. 1, 1975, p. 1-10.

Research output: Contribution to journalArticle

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