Daily injections of 100 mg phenobarbital/kg body wt stimulate substantial increases in liver growth. However, after 5 days of treatment there is no further growth in response to phenobarbital. At this time, the liver still grows after a single injection of 20 mg of 3-methylcholanthrene/kg body wt. It is concluded that the two drugs stimulate liver growth by different mechanisms, as they do liver drug metabolizing enzyme activity. In addition, we have shown that 100 mg phenobarbital/kg body wt in the immature male rat stimulates liver growth by both hepatocyte hypertrophy and hyperplasia, while 20 mg 3-methylcholanthrene/kg body wt with or without phenobarbital pretreatment stimulates only cell hypertrophy. Neither drug significantly affects mitotic activity in littoral or bile duct cells.
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Clinical Biochemistry