Stereotactic radiosurgery improves locomotor recovery after spinal cord injury in rats

Richard J. Zeman, Xialing Wen, Nengtai Ouyang, Ronald Rocchio, Lynn Shih, Alan Alfieri, Chitti Moorthy, Joseph D. Etlinger

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVE: Currently, because of the precision of stereotactic radiosurgery, radiation can now be delivered by techniques that shape the radiation beam to the tissue target for a variety of clinical applications. This avoids unnecessary and potentially damaging irradiation of surrounding tissues inherent in conventional irradiation, so that irradiation of the minimum volume of tissue necessary for optimal therapeutic benefit can be achieved. Although conventional x-irradiation has been shown to improve recovery from spinal cord injury in animals, the efficacy of targeted irradiation of the injured spinal cord has not been demonstrated previously. The purpose of these studies was to determine whether stereotactic x-irradiation of the injured spinal cord can enhance locomotor function and spare spinal cord tissue after contusion injury in a standard experimental model of spinal cord injury. METHODS: Contusion injury was produced in rats at the level of T10 with a weight-drop device, and doses of x-irradiation were delivered 2 hours after injury via a Novalis, 6-MeV linear accelerator shaped beam radiosurgery system (BrainLAB USA, Westchester, IL) in 4 sequential fractions, with beam angles 60 to 70 degrees apart, at a rate of 6.4 Gy/minute. The target volume was a 4 x 15-mm cylinder along the axis of the spinal cord, with the isocenter positioned at the contusion epicenter. Locomotor function was determined for 6 weeks after injury with the 21-point Basso, Beattie, and Bresnahan (BBB) locomotor scale and tissue sparing in histological sections of the spinal cord. RESULTS: Locomotor function recovered progressively during the 6-week postinjury observation period. BBB scores were significantly greater in the 10-Gy x-irradiated group compared with controls (9.4 versus 7.3; P < 0.05), indicating hind limb weight support or dorsal steppjng in contrast to hind limb joint mobility without weight bearing. Doses in the range of 2 to 10 Gy increased BBB scores progressively, whereas greater doses of 15 to 25 Gy were associated with lower BBB scores. The extent of locomotor recovery after treatment with x-irradiation correlated with measurements of spared spinal cord tissue at the contusion epicenter. CONCLUSION: These results suggest a beneficial role for stereotactic radiosurgery in a rat model of acute spinal cord contusion injury and raise hopes for human treatment strategies. Additional animal studies are needed to further define potential benefits.

Original languageEnglish (US)
Pages (from-to)981-987
Number of pages7
JournalNeurosurgery
Volume63
Issue number5
DOIs
StatePublished - Nov 2008
Externally publishedYes

Fingerprint

Radiosurgery
Spinal Cord Injuries
Spinal Cord
Contusions
Wounds and Injuries
Extremities
Radiation
Weights and Measures
Particle Accelerators
Weight-Bearing
Interleukin-4
Theoretical Models
Therapeutics
Joints
Observation
Equipment and Supplies

Keywords

  • Cavitation
  • Contusion
  • Locomotor recovery
  • Spinal cord injury
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Zeman, R. J., Wen, X., Ouyang, N., Rocchio, R., Shih, L., Alfieri, A., ... Etlinger, J. D. (2008). Stereotactic radiosurgery improves locomotor recovery after spinal cord injury in rats. Neurosurgery, 63(5), 981-987. https://doi.org/10.1227/01.NEU.0000330404.37092.3E

Stereotactic radiosurgery improves locomotor recovery after spinal cord injury in rats. / Zeman, Richard J.; Wen, Xialing; Ouyang, Nengtai; Rocchio, Ronald; Shih, Lynn; Alfieri, Alan; Moorthy, Chitti; Etlinger, Joseph D.

In: Neurosurgery, Vol. 63, No. 5, 11.2008, p. 981-987.

Research output: Contribution to journalArticle

Zeman, RJ, Wen, X, Ouyang, N, Rocchio, R, Shih, L, Alfieri, A, Moorthy, C & Etlinger, JD 2008, 'Stereotactic radiosurgery improves locomotor recovery after spinal cord injury in rats', Neurosurgery, vol. 63, no. 5, pp. 981-987. https://doi.org/10.1227/01.NEU.0000330404.37092.3E
Zeman, Richard J. ; Wen, Xialing ; Ouyang, Nengtai ; Rocchio, Ronald ; Shih, Lynn ; Alfieri, Alan ; Moorthy, Chitti ; Etlinger, Joseph D. / Stereotactic radiosurgery improves locomotor recovery after spinal cord injury in rats. In: Neurosurgery. 2008 ; Vol. 63, No. 5. pp. 981-987.
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