Stereotactic body radiotherapy for recurrent head and neck cancer: A critical review

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The management of patients with recurrent head and neck cancers remains a challenging clinical dilemma. Concerns over toxicity with re-irradiation have limited its use in the clinical setting. Stereotactic Body Radiation Therapy (SBRT) has emerged as a highly conformal and precise type of radiotherapy and has the advantage of sparing normal tissue. Although SBRT is an attractive treatment modality, its use in the clinic is limited, given the technically challenging nature of the procedure. In this review, we attempt to provide a comprehensive overview of the role of re-irradiation in patients with recurrent head and neck cancers, with particular attention to the advent of SBRT and its use with systemic therapies such as cetuximab. In the second portion of this review, we present our systematic review of published experiences with SBRT in recurrent head and neck cancers in an attempt to provide data on response rates (RR), overall survival and toxicity.

Original languageEnglish (US)
JournalHead and Neck
DOIs
StateAccepted/In press - 2016

Fingerprint

Radiosurgery
Head and Neck Neoplasms
Radiotherapy
Conformal Radiotherapy
Survival Rate
Therapeutics
Re-Irradiation

Keywords

  • Carotid blowout
  • Cetuximab
  • Recurrent head and neck cancer
  • Reirradiation
  • Stereotactic body radiotherapy (SBRT)

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

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title = "Stereotactic body radiotherapy for recurrent head and neck cancer: A critical review",
abstract = "The management of patients with recurrent head and neck cancers remains a challenging clinical dilemma. Concerns over toxicity with re-irradiation have limited its use in the clinical setting. Stereotactic Body Radiation Therapy (SBRT) has emerged as a highly conformal and precise type of radiotherapy and has the advantage of sparing normal tissue. Although SBRT is an attractive treatment modality, its use in the clinic is limited, given the technically challenging nature of the procedure. In this review, we attempt to provide a comprehensive overview of the role of re-irradiation in patients with recurrent head and neck cancers, with particular attention to the advent of SBRT and its use with systemic therapies such as cetuximab. In the second portion of this review, we present our systematic review of published experiences with SBRT in recurrent head and neck cancers in an attempt to provide data on response rates (RR), overall survival and toxicity.",
keywords = "Carotid blowout, Cetuximab, Recurrent head and neck cancer, Reirradiation, Stereotactic body radiotherapy (SBRT)",
author = "Sujith Baliga and Rafi Kabarriti and Nitin Ohri and Hilda Haynes-Lewis and Ravindra Yaparpalvi and Shalom Kalnicki and Garg, {Madhur K.}",
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journal = "Head and Neck",
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T1 - Stereotactic body radiotherapy for recurrent head and neck cancer

T2 - A critical review

AU - Baliga, Sujith

AU - Kabarriti, Rafi

AU - Ohri, Nitin

AU - Haynes-Lewis, Hilda

AU - Yaparpalvi, Ravindra

AU - Kalnicki, Shalom

AU - Garg, Madhur K.

PY - 2016

Y1 - 2016

N2 - The management of patients with recurrent head and neck cancers remains a challenging clinical dilemma. Concerns over toxicity with re-irradiation have limited its use in the clinical setting. Stereotactic Body Radiation Therapy (SBRT) has emerged as a highly conformal and precise type of radiotherapy and has the advantage of sparing normal tissue. Although SBRT is an attractive treatment modality, its use in the clinic is limited, given the technically challenging nature of the procedure. In this review, we attempt to provide a comprehensive overview of the role of re-irradiation in patients with recurrent head and neck cancers, with particular attention to the advent of SBRT and its use with systemic therapies such as cetuximab. In the second portion of this review, we present our systematic review of published experiences with SBRT in recurrent head and neck cancers in an attempt to provide data on response rates (RR), overall survival and toxicity.

AB - The management of patients with recurrent head and neck cancers remains a challenging clinical dilemma. Concerns over toxicity with re-irradiation have limited its use in the clinical setting. Stereotactic Body Radiation Therapy (SBRT) has emerged as a highly conformal and precise type of radiotherapy and has the advantage of sparing normal tissue. Although SBRT is an attractive treatment modality, its use in the clinic is limited, given the technically challenging nature of the procedure. In this review, we attempt to provide a comprehensive overview of the role of re-irradiation in patients with recurrent head and neck cancers, with particular attention to the advent of SBRT and its use with systemic therapies such as cetuximab. In the second portion of this review, we present our systematic review of published experiences with SBRT in recurrent head and neck cancers in an attempt to provide data on response rates (RR), overall survival and toxicity.

KW - Carotid blowout

KW - Cetuximab

KW - Recurrent head and neck cancer

KW - Reirradiation

KW - Stereotactic body radiotherapy (SBRT)

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