Stereotactic body radiation therapy in non-small-cell lung cancer: Linking radiobiological modeling and clinical outcome

Alexander Chi, Wolfgang A. Tomé, Jack Fowler, Ritsuko Komaki, Nam P. Nguyen, Minesh P. Mehta, James S. Welsh

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

For patients with peripheral, early-stage non-small-cell lung cancer, it has been found feasible to deliver 5 or fewer fractions of large doses through stereotactic body radiation therapy (SBRT) without causing severe early or late injury and with impressive tumor control. In this review, we employ radiobiological modeling with the linear quadratic formulation to explore the adequacy of various dose schedules used for tumor control in the lung as supported by clinical evidence, the influence of dose distribution and delivery time on local control, and how to decrease the likelihood of severe toxicity following SBRT. Furthermore, the validity of the linear quadratic formalism in the high dose range of SBRT for lung cancer is explored.

Original languageEnglish (US)
Pages (from-to)432-441
Number of pages10
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume34
Issue number4
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • linear quadratic formalism
  • non-small-cell lung cancer
  • radiation pneumonitis
  • stereotactic body radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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