TY - JOUR
T1 - Stereotactic body radiation therapy in non-small-cell lung cancer
T2 - Linking radiobiological modeling and clinical outcome
AU - Chi, Alexander
AU - Tomé, Wolfgang A.
AU - Fowler, Jack
AU - Komaki, Ritsuko
AU - Nguyen, Nam P.
AU - Mehta, Minesh P.
AU - Welsh, James S.
PY - 2011/8
Y1 - 2011/8
N2 - For patients with peripheral, early-stage non-small-cell lung cancer, it has been found feasible to deliver 5 or fewer fractions of large doses through stereotactic body radiation therapy (SBRT) without causing severe early or late injury and with impressive tumor control. In this review, we employ radiobiological modeling with the linear quadratic formulation to explore the adequacy of various dose schedules used for tumor control in the lung as supported by clinical evidence, the influence of dose distribution and delivery time on local control, and how to decrease the likelihood of severe toxicity following SBRT. Furthermore, the validity of the linear quadratic formalism in the high dose range of SBRT for lung cancer is explored.
AB - For patients with peripheral, early-stage non-small-cell lung cancer, it has been found feasible to deliver 5 or fewer fractions of large doses through stereotactic body radiation therapy (SBRT) without causing severe early or late injury and with impressive tumor control. In this review, we employ radiobiological modeling with the linear quadratic formulation to explore the adequacy of various dose schedules used for tumor control in the lung as supported by clinical evidence, the influence of dose distribution and delivery time on local control, and how to decrease the likelihood of severe toxicity following SBRT. Furthermore, the validity of the linear quadratic formalism in the high dose range of SBRT for lung cancer is explored.
KW - linear quadratic formalism
KW - non-small-cell lung cancer
KW - radiation pneumonitis
KW - stereotactic body radiation therapy
UR - http://www.scopus.com/inward/record.url?scp=79961171354&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79961171354&partnerID=8YFLogxK
U2 - 10.1097/COC.0b013e3181df4b3f
DO - 10.1097/COC.0b013e3181df4b3f
M3 - Review article
C2 - 20539207
AN - SCOPUS:79961171354
SN - 0277-3732
VL - 34
SP - 432
EP - 441
JO - American Journal of Clinical Oncology: Cancer Clinical Trials
JF - American Journal of Clinical Oncology: Cancer Clinical Trials
IS - 4
ER -
