Stereoselective syntheses and evaluation of compounds in the 8-desmethylepothilone a series: Some surprising observations regarding their chemical and biological properties

Aaron Balog, Peter Bertinato, Dai Shi Su, Dongfang Meng, Erik Sorensen, Samuel J. Danishefsky, Yu Huang Zheng, Ting Chao Chou, Lifeng He, Susan B. Horwitz

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The title compounds have been synthesized in a convergent way by recourse to a Weiler type dianion construction.

Original languageEnglish (US)
Pages (from-to)4529-4532
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number26
DOIs
Publication statusPublished - Jun 30 1997

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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