Abstract
(Chemical Equation Presented) The reaction of 2,2-dibromo-1-methyl- cyclopropanecarbonitrile (1) with i-PrMgCl in Et2O/CH 2Cl2 provides the cis-magnesium-carbenoid (2), which reacts with high retention of configuration with various electrophiles. If E = SPh, a stereoselective generation of a quaternary center via a sequential Br/Mg- and sulfoxide/Mg-exchange can be achieved.
Original language | English (US) |
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Pages (from-to) | 3789-3791 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 17 |
DOIs | |
State | Published - Aug 18 2005 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry