Steganacin: An inhibitor of HeLa cell growth and microtubule assembly in vitro

Peter B. Schiff, Andrew S. Kende, Susan Band Horwitz

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

The plant derivative steganacin, an antitumor compound, blocks the replication of HeLa cells in mitosis. Steganacin inhibits microtubule assembly in vitro (ID50 = 1.5 μM) and is a competitive inhibitor of colchicine binding to purified tubulin (Ki = 3.1 μM). The structure-activity relationships of steganacin and a series of analogues are reported.

Original languageEnglish (US)
Pages (from-to)737-746
Number of pages10
JournalBiochemical and Biophysical Research Communications
Volume85
Issue number2
DOIs
StatePublished - Nov 29 1978

Fingerprint

Growth Inhibitors
Cell growth
HeLa Cells
Microtubules
Colchicine
Structure-Activity Relationship
Tubulin
Mitosis
Derivatives
steganacin
In Vitro Techniques

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Steganacin : An inhibitor of HeLa cell growth and microtubule assembly in vitro. / Schiff, Peter B.; Kende, Andrew S.; Band Horwitz, Susan.

In: Biochemical and Biophysical Research Communications, Vol. 85, No. 2, 29.11.1978, p. 737-746.

Research output: Contribution to journalArticle

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