The plant derivative steganacin, an antitumor compound, blocks the replication of HeLa cells in mitosis. Steganacin inhibits microtubule assembly in vitro (ID50 = 1.5 μM) and is a competitive inhibitor of colchicine binding to purified tubulin (Ki = 3.1 μM). The structure-activity relationships of steganacin and a series of analogues are reported.
|Original language||English (US)|
|Number of pages||10|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - Nov 29 1978|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology