Steganacin: An inhibitor of HeLa cell growth and microtubule assembly in vitro

Peter B. Schiff; Andrew S. Kende; Susan B. Horwitz

doi:10.1016/0006-291X(78)91223-8

Steganacin: An inhibitor of HeLa cell growth and microtubule assembly in vitro

Peter B. Schiff, Andrew S. Kende, Susan B. Horwitz

Molecular Pharmacology

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The plant derivative steganacin, an antitumor compound, blocks the replication of HeLa cells in mitosis. Steganacin inhibits microtubule assembly in vitro (ID₅₀ = 1.5 μM) and is a competitive inhibitor of colchicine binding to purified tubulin (K_i = 3.1 μM). The structure-activity relationships of steganacin and a series of analogues are reported.

Original language	English (US)
Pages (from-to)	737-746
Number of pages	10
Journal	Biochemical and Biophysical Research Communications
Volume	85
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(78)91223-8
State	Published - Nov 29 1978

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/0006-291X(78)91223-8

Cite this

@article{e007d27831154586bcd27c3e4915062a,

title = "Steganacin: An inhibitor of HeLa cell growth and microtubule assembly in vitro",

abstract = "The plant derivative steganacin, an antitumor compound, blocks the replication of HeLa cells in mitosis. Steganacin inhibits microtubule assembly in vitro (ID50 = 1.5 μM) and is a competitive inhibitor of colchicine binding to purified tubulin (Ki = 3.1 μM). The structure-activity relationships of steganacin and a series of analogues are reported.",

author = "Schiff, {Peter B.} and Kende, {Andrew S.} and Horwitz, {Susan B.}",

note = "Funding Information: This work was supported in part by American Cancer Society Grant CH-86 and United States Public Health Grant 1 ROl CA 23187. S.B.H. is a recipient of an Irma T. Hirsch1 Career Scientist Award. P.B.S. was supported by a Public Health Service Training Grant in Pharmacological Sciences 5T 32 G~07260.",

year = "1978",

month = nov,

day = "29",

doi = "10.1016/0006-291X(78)91223-8",

language = "English (US)",

volume = "85",

pages = "737--746",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Steganacin

T2 - An inhibitor of HeLa cell growth and microtubule assembly in vitro

AU - Schiff, Peter B.

AU - Kende, Andrew S.

AU - Horwitz, Susan B.

N1 - Funding Information: This work was supported in part by American Cancer Society Grant CH-86 and United States Public Health Grant 1 ROl CA 23187. S.B.H. is a recipient of an Irma T. Hirsch1 Career Scientist Award. P.B.S. was supported by a Public Health Service Training Grant in Pharmacological Sciences 5T 32 G~07260.

PY - 1978/11/29

Y1 - 1978/11/29

N2 - The plant derivative steganacin, an antitumor compound, blocks the replication of HeLa cells in mitosis. Steganacin inhibits microtubule assembly in vitro (ID50 = 1.5 μM) and is a competitive inhibitor of colchicine binding to purified tubulin (Ki = 3.1 μM). The structure-activity relationships of steganacin and a series of analogues are reported.

AB - The plant derivative steganacin, an antitumor compound, blocks the replication of HeLa cells in mitosis. Steganacin inhibits microtubule assembly in vitro (ID50 = 1.5 μM) and is a competitive inhibitor of colchicine binding to purified tubulin (Ki = 3.1 μM). The structure-activity relationships of steganacin and a series of analogues are reported.

UR - http://www.scopus.com/inward/record.url?scp=0018279165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018279165&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(78)91223-8

DO - 10.1016/0006-291X(78)91223-8

M3 - Article

C2 - 736931

AN - SCOPUS:0018279165

SN - 0006-291X

VL - 85

SP - 737

EP - 746

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Steganacin: An inhibitor of HeLa cell growth and microtubule assembly in vitro

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this