Steganacin: An inhibitor of HeLa cell growth and microtubule assembly in vitro

Peter B. Schiff, Andrew S. Kende, Susan B. Horwitz

Research output: Contribution to journalArticle

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Abstract

The plant derivative steganacin, an antitumor compound, blocks the replication of HeLa cells in mitosis. Steganacin inhibits microtubule assembly in vitro (ID50 = 1.5 μM) and is a competitive inhibitor of colchicine binding to purified tubulin (Ki = 3.1 μM). The structure-activity relationships of steganacin and a series of analogues are reported.

Original languageEnglish (US)
Pages (from-to)737-746
Number of pages10
JournalBiochemical and Biophysical Research Communications
Volume85
Issue number2
DOIs
Publication statusPublished - Nov 29 1978

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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