Statins

Potentially neuroprotective agents

Sergey V. Pisklakov, Anuradha Patel

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The aim of this chapter is to assess the experimental and clinical evidence regarding potential neuroprotective effects of statins and their possible perioperative benefit. Statins are drugs used to control cholesterol disorders and prevent cardiovascular diseases by four mechanisms: improvement of endothelial function, modulation of inflammatory responses, maintenance of plaque stability, and prevention of thrombus formation. It is possible that these various effects may also be neuroprotective. The anti-inflammatory effects of statins on endothelial cell mechanisms are better understood than their role in neuroprotection or tumoral apoptosis and evidence is only just emerging that statins may be beneficial. Data regarding perioperative use of statins in neurosurgery is scarce, controversial and inconclusive since there is a lack of convincing randomized, prospective clinical trials. More trials in humans are needed to determine whether statins could contribute to the current management of neurosurgical diseases. Not much is known about utilizing statins as a prophylactic treatment and some would probably advocate that we should be treating 'at risk' patients with statins perioperatively or at least it is important to try to put this into a clinical perspective..

Original languageEnglish (US)
Title of host publicationStatins: Medical Uses, Mechanisms of Action and Clinical Outcomes
PublisherNova Science Publishers, Inc.
Pages27-37
Number of pages11
ISBN (Print)9781634630962, 9781634630573
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Neuroprotective Agents
Neurosurgery
Disease Management
Thrombosis
Anti-Inflammatory Agents
Cardiovascular Diseases
Randomized Controlled Trials
Endothelial Cells
Cholesterol
Maintenance
Apoptosis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pisklakov, S. V., & Patel, A. (2014). Statins: Potentially neuroprotective agents. In Statins: Medical Uses, Mechanisms of Action and Clinical Outcomes (pp. 27-37). Nova Science Publishers, Inc..

Statins : Potentially neuroprotective agents. / Pisklakov, Sergey V.; Patel, Anuradha.

Statins: Medical Uses, Mechanisms of Action and Clinical Outcomes. Nova Science Publishers, Inc., 2014. p. 27-37.

Research output: Chapter in Book/Report/Conference proceedingChapter

Pisklakov, SV & Patel, A 2014, Statins: Potentially neuroprotective agents. in Statins: Medical Uses, Mechanisms of Action and Clinical Outcomes. Nova Science Publishers, Inc., pp. 27-37.
Pisklakov SV, Patel A. Statins: Potentially neuroprotective agents. In Statins: Medical Uses, Mechanisms of Action and Clinical Outcomes. Nova Science Publishers, Inc. 2014. p. 27-37
Pisklakov, Sergey V. ; Patel, Anuradha. / Statins : Potentially neuroprotective agents. Statins: Medical Uses, Mechanisms of Action and Clinical Outcomes. Nova Science Publishers, Inc., 2014. pp. 27-37
@inbook{c1bf986fea4d424fa51b94f8ffdfb868,
title = "Statins: Potentially neuroprotective agents",
abstract = "The aim of this chapter is to assess the experimental and clinical evidence regarding potential neuroprotective effects of statins and their possible perioperative benefit. Statins are drugs used to control cholesterol disorders and prevent cardiovascular diseases by four mechanisms: improvement of endothelial function, modulation of inflammatory responses, maintenance of plaque stability, and prevention of thrombus formation. It is possible that these various effects may also be neuroprotective. The anti-inflammatory effects of statins on endothelial cell mechanisms are better understood than their role in neuroprotection or tumoral apoptosis and evidence is only just emerging that statins may be beneficial. Data regarding perioperative use of statins in neurosurgery is scarce, controversial and inconclusive since there is a lack of convincing randomized, prospective clinical trials. More trials in humans are needed to determine whether statins could contribute to the current management of neurosurgical diseases. Not much is known about utilizing statins as a prophylactic treatment and some would probably advocate that we should be treating 'at risk' patients with statins perioperatively or at least it is important to try to put this into a clinical perspective..",
author = "Pisklakov, {Sergey V.} and Anuradha Patel",
year = "2014",
month = "1",
day = "1",
language = "English (US)",
isbn = "9781634630962",
pages = "27--37",
booktitle = "Statins: Medical Uses, Mechanisms of Action and Clinical Outcomes",
publisher = "Nova Science Publishers, Inc.",

}

TY - CHAP

T1 - Statins

T2 - Potentially neuroprotective agents

AU - Pisklakov, Sergey V.

AU - Patel, Anuradha

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The aim of this chapter is to assess the experimental and clinical evidence regarding potential neuroprotective effects of statins and their possible perioperative benefit. Statins are drugs used to control cholesterol disorders and prevent cardiovascular diseases by four mechanisms: improvement of endothelial function, modulation of inflammatory responses, maintenance of plaque stability, and prevention of thrombus formation. It is possible that these various effects may also be neuroprotective. The anti-inflammatory effects of statins on endothelial cell mechanisms are better understood than their role in neuroprotection or tumoral apoptosis and evidence is only just emerging that statins may be beneficial. Data regarding perioperative use of statins in neurosurgery is scarce, controversial and inconclusive since there is a lack of convincing randomized, prospective clinical trials. More trials in humans are needed to determine whether statins could contribute to the current management of neurosurgical diseases. Not much is known about utilizing statins as a prophylactic treatment and some would probably advocate that we should be treating 'at risk' patients with statins perioperatively or at least it is important to try to put this into a clinical perspective..

AB - The aim of this chapter is to assess the experimental and clinical evidence regarding potential neuroprotective effects of statins and their possible perioperative benefit. Statins are drugs used to control cholesterol disorders and prevent cardiovascular diseases by four mechanisms: improvement of endothelial function, modulation of inflammatory responses, maintenance of plaque stability, and prevention of thrombus formation. It is possible that these various effects may also be neuroprotective. The anti-inflammatory effects of statins on endothelial cell mechanisms are better understood than their role in neuroprotection or tumoral apoptosis and evidence is only just emerging that statins may be beneficial. Data regarding perioperative use of statins in neurosurgery is scarce, controversial and inconclusive since there is a lack of convincing randomized, prospective clinical trials. More trials in humans are needed to determine whether statins could contribute to the current management of neurosurgical diseases. Not much is known about utilizing statins as a prophylactic treatment and some would probably advocate that we should be treating 'at risk' patients with statins perioperatively or at least it is important to try to put this into a clinical perspective..

UR - http://www.scopus.com/inward/record.url?scp=84956562191&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956562191&partnerID=8YFLogxK

M3 - Chapter

SN - 9781634630962

SN - 9781634630573

SP - 27

EP - 37

BT - Statins: Medical Uses, Mechanisms of Action and Clinical Outcomes

PB - Nova Science Publishers, Inc.

ER -