Stage 4 squamous cell carcinoma of the tongue in a child: Complete response to chemoradiotherapy

Sandeep Soni, Eva Radel, Richard V. Smith, Morris Edelman, Ron Sattenberg, Scott Wadler, Jonathan J. Beitler

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

This report describes a complete response to a chemoradiotherapy regimen in a child with an advanced and unresectable squamous cell carcinoma of the tongue. An 8-year-old girl had stage 4 squamous cell carcinoma of the tongue (T4N2M0), causing severe trismus and dysphagia. She received hyperfractionated external beam radiotherapy (total 74.4 Gy) and concomitant intravenous infusion of hydroxyurea (0.313 mg/m 2 per min) for 43 days. Grade 3 mucositis and myelosuppression were the main toxicities. There was marked symptomatic improvement, and the patient achieved a complete response. She is disease-free 24 months after treatment, and all the acute symptoms have resolved. The regimen was well tolerated with acceptable toxicity and led to a complete objective response. This regimen needs further evaluation to confirm its efficacy and to ascertain its long-term effects in children.

Original languageEnglish (US)
Pages (from-to)612-615
Number of pages4
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume23
Issue number9
DOIs
StatePublished - Jan 1 2001

Keywords

  • Chemoradiotherapy
  • Chemotherapy
  • Hydroxyurea
  • Hyperfractionated external radiation therapy
  • Pediatric squamous cell carcinoma
  • Radiotherapy
  • Tongue

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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