Splenic complications in malaria

Case report and review

Barry S. Zingman, Brant L. Viner

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

Clinicians are increasingly confronted with diagnosis and management of malarial complications. In nonfalciparum malaria, severe complications usually involve the spleen, most notably among them the condition termed spontaneous splenic rupture. A case of infection due to Plasmodium malariae resulting in a symptomatic splenic hematoma is presented. Malarial splenic enlargement and pathology are reviewed, as well as splenic complications such as spontaneous rupture, hematoma, hyperreactive malarial syndrome, hypersplenism, ectopic spleen, torsion, and formation of cysts. Also evaluated are the 11 reported cases of spontaneous splenic rupture in malaria in the English-language literature from 1960 to 1991. Most cases of spontaneous splenic rupture in malaria occur during acute infection and are associated with Plasmodium vivax. Lack of prior immunity to malaria appears to be a major predisposing factor. Increasingly, splenic complications are managed by supportive care and spleen-conserving procedures to avoid postoperative and asplenic morbidity.

Original languageEnglish (US)
Pages (from-to)223-232
Number of pages10
JournalClinical Infectious Diseases
Volume16
Issue number2
StatePublished - Feb 1993
Externally publishedYes

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Spontaneous Rupture
Splenic Rupture
Malaria
Spleen
Hematoma
Plasmodium malariae
Hypersplenism
Plasmodium vivax
Managed Care Programs
Infection
Causality
Cysts
Immunity
Language
Pathology
Morbidity

ASJC Scopus subject areas

  • Immunology

Cite this

Splenic complications in malaria : Case report and review. / Zingman, Barry S.; Viner, Brant L.

In: Clinical Infectious Diseases, Vol. 16, No. 2, 02.1993, p. 223-232.

Research output: Contribution to journalArticle

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