Spine modifications associated with long-term potentiation

Modification of neuronal connections is essential for the development of the nervous system and learning and memory functions of the mature brain. Structural modifications, such as modification of dendritic spines where the modified synapses reside, accompany and may even be required for these functional modifications. Recent advances in fluorescence microscopy, coupled with molecular approaches, prompted a rapid advance in the authorsg™ understanding of spine remodeling associated with synaptic plasticity, especially long-term potentiation. In this article, they review recent progress in this field, with focus on the potential functions of spine remodeling and key issues to be resolved.