Spatial and temporal sequence of corneal crystal deposition in nephropathic cystinosis

Ronald B. Melles, Jerry A. Schneider, Narsing A. Rao, Barrett Katz

Research output: Contribution to journalArticle

19 Scopus citations


We studied 15 patients with infantile nephropathic cystinosis. We found that anterior corneal cystine crystal deposition began early in life and proceeded posteriorly as the patient aged; deposition advanced more rapidly in the periphery. Ultrastructural analysis of a corneal button obtained from a 20-year-old patient undergoing corneal transplantation confirmed our clinical observations that crystals were deposited throughout the entire central stroma.

Original languageEnglish (US)
Pages (from-to)598-604
Number of pages7
JournalAmerican journal of ophthalmology
Issue number6
StatePublished - Dec 1987


ASJC Scopus subject areas

  • Ophthalmology

Cite this