Somatic mutations and aging: A re-evaluation

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Abstract

Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)117-135
Number of pages19
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume447
Issue number1
DOIs
Publication statusPublished - Jan 17 2000
Externally publishedYes

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Keywords

  • Aging
  • DNA repair
  • Genome instability
  • Somatic mutation
  • Transgenic and knockout mice

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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