Somatic mutations and aging: A re-evaluation

J. Vijg

doi:10.1016/S0027-5107(99)00202-X

Somatic mutations and aging: A re-evaluation

J. Vijg

Research output: Contribution to journal › Article › peer-review

198 Scopus citations

Abstract

Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed. (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	117-135
Number of pages	19
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	447
Issue number	1
DOIs	https://doi.org/10.1016/S0027-5107(99)00202-X
State	Published - Jan 17 2000
Externally published	Yes

Keywords

Aging
DNA repair
Genome instability
Somatic mutation
Transgenic and knockout mice

ASJC Scopus subject areas

Molecular Biology
Genetics
Health, Toxicology and Mutagenesis

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10.1016/S0027-5107(99)00202-X

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title = "Somatic mutations and aging: A re-evaluation",

abstract = "Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed. (C) 2000 Elsevier Science B.V.",

keywords = "Aging, DNA repair, Genome instability, Somatic mutation, Transgenic and knockout mice",

author = "J. Vijg",

note = "Funding Information: I thank Drs. Huber Warner and Mitchell S. Turker for critically reading the manuscript and their useful comments, and Ms. Julia Perkins for her help with the preparation of the manuscript. This work was supported by NIH grants PO1 1801 AG10829-01, 1 P30 AG13319-05 and 1 RO1 ES/CA 08797-01.",

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N2 - Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed. (C) 2000 Elsevier Science B.V.

AB - Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed. (C) 2000 Elsevier Science B.V.

KW - Aging

KW - DNA repair

KW - Genome instability

KW - Somatic mutation

KW - Transgenic and knockout mice

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Somatic mutations and aging: A re-evaluation

Abstract

Keywords

ASJC Scopus subject areas

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