TY - JOUR
T1 - Somatic mutations and aging
T2 - A re-evaluation
AU - Vijg, J.
N1 - Funding Information:
I thank Drs. Huber Warner and Mitchell S. Turker for critically reading the manuscript and their useful comments, and Ms. Julia Perkins for her help with the preparation of the manuscript. This work was supported by NIH grants PO1 1801 AG10829-01, 1 P30 AG13319-05 and 1 RO1 ES/CA 08797-01.
PY - 2000/1/17
Y1 - 2000/1/17
N2 - Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed. (C) 2000 Elsevier Science B.V.
AB - Aging has been explained in terms of an accumulation of mutations in the genome of somatic cells, leading to tissue atrophy and neoplasms, as well as increased loss of function. Recent advances in transgenic mouse modeling and genomics technology have created, for the first time, the opportunity to begin testing this theory. In this paper the existing evidence for a possible role of somatic mutation accumulation in aging will be re-evaluated on the basis of the evolutionary logic of aging and recent insights in genome structure and function. New strategies for investigating the relationship between genome instability, mutation accumulation and aging will be discussed. (C) 2000 Elsevier Science B.V.
KW - Aging
KW - DNA repair
KW - Genome instability
KW - Somatic mutation
KW - Transgenic and knockout mice
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U2 - 10.1016/S0027-5107(99)00202-X
DO - 10.1016/S0027-5107(99)00202-X
M3 - Article
C2 - 10686308
AN - SCOPUS:0033953142
SN - 0027-5107
VL - 447
SP - 117
EP - 135
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1
ER -