Solvent-controlled asymmetric strecker reaction: Stereoselective synthesis of α-trifluoromethylated α-amino acids

Hua Wang, Xiaoming Zhao, Youhua Li, Long Lu

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Stereoselective approaches to α-trifluoromethylated α-amino acids (α-Tim AAs) have been developed. The stereoconfigurations of the resulting α-Tfm AA precursors were well controlled by using different solvents. The optically active (S)-2-amino-2-phenyl-1,1,1-trifluoropropanoic acid was synthesized by this method.

Original languageEnglish (US)
Pages (from-to)1379-1381
Number of pages3
JournalOrganic Letters
Volume8
Issue number7
DOIs
StatePublished - Mar 30 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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