Solvent-controlled asymmetric strecker reaction

Stereoselective synthesis of α-trifluoromethylated α-amino acids

Hua Wang, Xiaoming Zhao, Youhua Li, Long Lu

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Stereoselective approaches to α-trifluoromethylated α-amino acids (α-Tim AAs) have been developed. The stereoconfigurations of the resulting α-Tfm AA precursors were well controlled by using different solvents. The optically active (S)-2-amino-2-phenyl-1,1,1-trifluoropropanoic acid was synthesized by this method.

Original languageEnglish (US)
Pages (from-to)1379-1381
Number of pages3
JournalOrganic Letters
Volume8
Issue number7
DOIs
StatePublished - Mar 30 2006
Externally publishedYes

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amino acids
Amino Acids
acids
Acids
synthesis

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Solvent-controlled asymmetric strecker reaction : Stereoselective synthesis of α-trifluoromethylated α-amino acids. / Wang, Hua; Zhao, Xiaoming; Li, Youhua; Lu, Long.

In: Organic Letters, Vol. 8, No. 7, 30.03.2006, p. 1379-1381.

Research output: Contribution to journalArticle

Wang, Hua ; Zhao, Xiaoming ; Li, Youhua ; Lu, Long. / Solvent-controlled asymmetric strecker reaction : Stereoselective synthesis of α-trifluoromethylated α-amino acids. In: Organic Letters. 2006 ; Vol. 8, No. 7. pp. 1379-1381.
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