Smoking cessation and lung cancer mortality in a cohort of middle-aged Canadian women

Bo Zhang, Roberta Ferrence, Joanna Cohen, Susan Bondy, Mary Jane Ashley, Jürgen Rehm, Meera Jain, Thomas E. Rohan, Anthony Miller

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To determine the impact of smoking cessation on lung cancer mortality among women. Methods: Survival analysis is used to assess the effect of smoking cessation on lung cancer death in the dietary cohort of 49,165 women aged 40 to 59 years enrolled in the Canadian National Breast Screening Study. Results: During an average of 10.3 years of follow-up, 106 women died of lung cancer. The risk of lung cancer mortality among women who quit before age 50 (HR = 0.26; 95% CI, 0.13-0.55 among women who quit at ages 40-49) or quit in the previous 10 years (HR = 0.39; 95% CI, 0.22-0.69) is substantially lower than the risk among current smokers. Women who quit after age 40 or have quit for less than 20 years are at substantially higher risk of lung cancer mortality compared with never smokers. Both duration of smoking cessation and age at quitting have independent effects on lung cancer mortality, after controlling for number of cigarettes smoked per day and number of years smoked, as well as other potential confounding variables. Conclusion: These findings suggest that programs and policies to promote early cessation of smoking and prevention of relapse should be a public health priority.

Original languageEnglish (US)
Pages (from-to)302-309
Number of pages8
JournalAnnals of Epidemiology
Volume15
Issue number4
DOIs
StatePublished - Apr 2005

Fingerprint

Smoking Cessation
Lung Neoplasms
Mortality
Health Priorities
Confounding Factors (Epidemiology)
Survival Analysis
Secondary Prevention
Tobacco Products
Breast
Public Health

Keywords

  • Cohort Study
  • Lung Cancer
  • Mortality
  • Smoking Cessation
  • Survival Analysis
  • Women

ASJC Scopus subject areas

  • Medicine(all)
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Zhang, B., Ferrence, R., Cohen, J., Bondy, S., Ashley, M. J., Rehm, J., ... Miller, A. (2005). Smoking cessation and lung cancer mortality in a cohort of middle-aged Canadian women. Annals of Epidemiology, 15(4), 302-309. https://doi.org/10.1016/j.annepidem.2004.08.013

Smoking cessation and lung cancer mortality in a cohort of middle-aged Canadian women. / Zhang, Bo; Ferrence, Roberta; Cohen, Joanna; Bondy, Susan; Ashley, Mary Jane; Rehm, Jürgen; Jain, Meera; Rohan, Thomas E.; Miller, Anthony.

In: Annals of Epidemiology, Vol. 15, No. 4, 04.2005, p. 302-309.

Research output: Contribution to journalArticle

Zhang, B, Ferrence, R, Cohen, J, Bondy, S, Ashley, MJ, Rehm, J, Jain, M, Rohan, TE & Miller, A 2005, 'Smoking cessation and lung cancer mortality in a cohort of middle-aged Canadian women', Annals of Epidemiology, vol. 15, no. 4, pp. 302-309. https://doi.org/10.1016/j.annepidem.2004.08.013
Zhang, Bo ; Ferrence, Roberta ; Cohen, Joanna ; Bondy, Susan ; Ashley, Mary Jane ; Rehm, Jürgen ; Jain, Meera ; Rohan, Thomas E. ; Miller, Anthony. / Smoking cessation and lung cancer mortality in a cohort of middle-aged Canadian women. In: Annals of Epidemiology. 2005 ; Vol. 15, No. 4. pp. 302-309.
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