Small cell neuroendocrine carcinoma of the endometrium

K. H. van Hoeven, Jude A. Hudock, James M. Woodruff, Mark J. Suhrland

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Ten cases of endometrial small cell neuroendocrine carcinoma are described. The ages of the patients ranged from 50 to 75 years (mean, 64 years). Most of the tumors were bulky, intraluminal masses that invaded at least half of the myometrial wall. Small cells were the only malignant element in two tumors. In the other eight, there were admixed elements of adenocarcinoma (five), adenosquamous carcinoma (two), or heterologous mesodermal mixed tumor (one). Histologic examination of metastatic deposits in six cases revealed solely small cells in all but one. Immunohistochemical evidence of neuroendocrine differentiation was demonstrated in all tumors using the markers chromogranin, synaptophysin, leu-7, or neuron-specific enolase. Six of these tumors were originally interpreted as mesodermal mixed tumors with a homologous, stromal-type sarcomatous component at initial pathologic examination, but were reclassified as carcinoma. Clinical follow-up of these 10 patients and an additional seven well-documented patients reported in the literature provided strong evidence for the aggressive nature of this neoplasm. Endometrial small cell neuroendocrine carcinoma is a rare, but aggressive neoplasm that can commonly be mistaken for a homologous-type mesodermal mixed tumor.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalInternational Journal of Gynecological Pathology
Volume14
Issue number1
StatePublished - 1995

Fingerprint

Neuroendocrine Carcinoma
Small Cell Carcinoma
Endometrial Neoplasms
Mesodermal Mixed Tumor
Neoplasms
Adenosquamous Carcinoma
Chromogranins
Synaptophysin
Phosphopyruvate Hydratase
Tumor Biomarkers
Adenocarcinoma
Carcinoma

Keywords

  • Endometrium
  • Neuroendocrine tumors
  • Small cell Carcinoma

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pathology and Forensic Medicine

Cite this

Small cell neuroendocrine carcinoma of the endometrium. / van Hoeven, K. H.; Hudock, Jude A.; Woodruff, James M.; Suhrland, Mark J.

In: International Journal of Gynecological Pathology, Vol. 14, No. 1, 1995, p. 21-29.

Research output: Contribution to journalArticle

van Hoeven, KH, Hudock, JA, Woodruff, JM & Suhrland, MJ 1995, 'Small cell neuroendocrine carcinoma of the endometrium', International Journal of Gynecological Pathology, vol. 14, no. 1, pp. 21-29.
van Hoeven, K. H. ; Hudock, Jude A. ; Woodruff, James M. ; Suhrland, Mark J. / Small cell neuroendocrine carcinoma of the endometrium. In: International Journal of Gynecological Pathology. 1995 ; Vol. 14, No. 1. pp. 21-29.
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