Slight Renal Effect of Mercury from Amalgam Fillings

Serife Eti, Richard Weisman, Robert Hoffman, M. M. Reidenberg

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Abstract: The current study was to answer the question: Is enough mercury absorbed from dental amalgam fillings to produce renal damage? One hundred healthy adults (18–44 years old) filled out health questionnaires and voided urine samples. Urine mercury concentration and N‐acetyl‐β‐glucosaminidase (NAG) were measured. Subjects were grouped into those having amalgam fillings (N=66) and those without (N=34). Median (95% Confidence Interval) urine mercury was 1 (1–2) and 0 (0–0.6) ng/ml (P<0.01) and median urine NAG was 23 (18–27) and 16 (11–18) units (P<0.05) in the two groups respectively. People with mercury amalgam fillings excreted slightly more mercury than people without them, and have a very small increase in urinary NAG excretion that is probably of no clinical significance. This dose of mercury absorbed from amalgam appears to be too little to be a public health hazard for renal injury. 1995 Nordic Pharmacological Society

Original languageEnglish (US)
Pages (from-to)47-49
Number of pages3
JournalPharmacology & Toxicology
Issue number1
StatePublished - Jan 1995
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Health, Toxicology and Mutagenesis


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