Sleep and wakefulness modulation of the neuronal firing in the auditory cortex of the guinea pig

Jose L. Pena, Lucía Pérez-Perera, Marcel Bouvier, Ricardo A. Velluti

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Sleep-related changes - including modification in sensory processing - that influence brain and body functions, occur during both slow wave and paradoxical sleep. Our aim was to investigate how cortical auditory neurons behave during the sleep/waking cycle, and to study cell firing patterns in relation to the processing of auditory information without the interference of anesthetic drugs. We recorded single cells in the A region of the auditory cortex in restrained, chronically-implanted guinea pigs, and compared their evoked and spontaneous activity during sleep stages and quiet wakefulness. A new classification of the unit's responses to simple sound during wakefulness is presented. Moreover, a number of the neurons in the primary auditory cortex exhibited significant quantitative changes in their evoked or spontaneous firing rates. These changes could be correlated to sleep stages or wakefulness in 42.2% to 58.3% of the sampled neurons. A similar population did not show behavioral related changes in firing rates. Our results indicate that the responsiveness of the auditory system during sleep may be considered partially preserved. An important result was that spontaneous and evoked activity may vary in opposite directions, i.e., the evoked activity could increase while the spontaneous activity decrease or vice versa. Then, a general question was proposed: is the increased spontaneous activity in the auditory cortex, particularly during PS, related to auditory hypnic 'images'? The studied cortical auditory neurons exhibit changes in their firing rates in correlation to stages of sleep and wakefulness. This is consistent with the hypothesis that a general shift in the neuronal networks involved in sensory processing occurs during sleep.

Original languageEnglish (US)
Pages (from-to)463-470
Number of pages8
JournalBrain Research
Volume816
Issue number2
DOIs
StatePublished - Jan 23 1999
Externally publishedYes

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Auditory Cortex
Wakefulness
Sleep
Guinea Pigs
Sleep Stages
Neurons
REM Sleep
Automatic Data Processing
Anesthetics
Brain
Population

Keywords

  • Auditory cortex
  • In vivo
  • Sleep
  • Unitary activity
  • Wakefulness

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sleep and wakefulness modulation of the neuronal firing in the auditory cortex of the guinea pig. / Pena, Jose L.; Pérez-Perera, Lucía; Bouvier, Marcel; Velluti, Ricardo A.

In: Brain Research, Vol. 816, No. 2, 23.01.1999, p. 463-470.

Research output: Contribution to journalArticle

Pena, Jose L. ; Pérez-Perera, Lucía ; Bouvier, Marcel ; Velluti, Ricardo A. / Sleep and wakefulness modulation of the neuronal firing in the auditory cortex of the guinea pig. In: Brain Research. 1999 ; Vol. 816, No. 2. pp. 463-470.
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