Abstract
We describe here the development, verification and validation of the SLE-key® rule-out test for a definitive rule-out of a diagnosis of systemic lupus erythematosus (SLE). The test uses the proprietary iCHIP® micro-array technology platform (Fattal et al., 2010) to identify discriminating patterns of circulating autoantibodies among SLE patients compared with self-declared healthy individuals. Given the challenges associated with the diagnosis of SLE and the healthcare costs of delayed diagnosis and misdiagnosis, a definitive rule-out test can provide significant clinical benefits to patients and potentially major cost savings to healthcare systems.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-6 |
| Number of pages | 6 |
| Journal | Journal of Immunological Methods |
| Volume | 429 |
| DOIs | |
| State | Published - Feb 1 2016 |
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Keywords
- Autoantibodies
- Diagnosis
- ICHIP
- Microarray
- Multivariate classifier
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
SLE-key® rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus : Developing the ImmunArray iCHIP®. / Putterman, Chaim; Wu, Alan; Reiner-Benaim, Anat; Batty, D. Scott; Sanz, Ignacio; Oates, Jim; Jakobi, Keren; Petri, Michelle; Safer, Pennina; Gerwien, Robert; Sorek, Rachel; Blumenstein, Yakov; Cohen, Irun R.
In: Journal of Immunological Methods, Vol. 429, 01.02.2016, p. 1-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - SLE-key® rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus
T2 - Developing the ImmunArray iCHIP®
AU - Putterman, Chaim
AU - Wu, Alan
AU - Reiner-Benaim, Anat
AU - Batty, D. Scott
AU - Sanz, Ignacio
AU - Oates, Jim
AU - Jakobi, Keren
AU - Petri, Michelle
AU - Safer, Pennina
AU - Gerwien, Robert
AU - Sorek, Rachel
AU - Blumenstein, Yakov
AU - Cohen, Irun R.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - We describe here the development, verification and validation of the SLE-key® rule-out test for a definitive rule-out of a diagnosis of systemic lupus erythematosus (SLE). The test uses the proprietary iCHIP® micro-array technology platform (Fattal et al., 2010) to identify discriminating patterns of circulating autoantibodies among SLE patients compared with self-declared healthy individuals. Given the challenges associated with the diagnosis of SLE and the healthcare costs of delayed diagnosis and misdiagnosis, a definitive rule-out test can provide significant clinical benefits to patients and potentially major cost savings to healthcare systems.
AB - We describe here the development, verification and validation of the SLE-key® rule-out test for a definitive rule-out of a diagnosis of systemic lupus erythematosus (SLE). The test uses the proprietary iCHIP® micro-array technology platform (Fattal et al., 2010) to identify discriminating patterns of circulating autoantibodies among SLE patients compared with self-declared healthy individuals. Given the challenges associated with the diagnosis of SLE and the healthcare costs of delayed diagnosis and misdiagnosis, a definitive rule-out test can provide significant clinical benefits to patients and potentially major cost savings to healthcare systems.
KW - Autoantibodies
KW - Diagnosis
KW - ICHIP
KW - Microarray
KW - Multivariate classifier
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84957538079&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957538079&partnerID=8YFLogxK
U2 - 10.1016/j.jim.2015.12.003
DO - 10.1016/j.jim.2015.12.003
M3 - Article
C2 - 26678162
AN - SCOPUS:84957538079
VL - 429
SP - 1
EP - 6
JO - Journal of Immunological Methods
JF - Journal of Immunological Methods
SN - 0022-1759
ER -