@article{66e87673be3b46c290b1f49d6893c02e,
title = "SLE-key{\textregistered} rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP{\textregistered}",
abstract = "We describe here the development, verification and validation of the SLE-key{\textregistered} rule-out test for a definitive rule-out of a diagnosis of systemic lupus erythematosus (SLE). The test uses the proprietary iCHIP{\textregistered} micro-array technology platform (Fattal et al., 2010) to identify discriminating patterns of circulating autoantibodies among SLE patients compared with self-declared healthy individuals. Given the challenges associated with the diagnosis of SLE and the healthcare costs of delayed diagnosis and misdiagnosis, a definitive rule-out test can provide significant clinical benefits to patients and potentially major cost savings to healthcare systems.",
keywords = "Autoantibodies, Diagnosis, ICHIP, Microarray, Multivariate classifier, Systemic lupus erythematosus",
author = "Chaim Putterman and Alan Wu and Anat Reiner-Benaim and Batty, {D. Scott} and Ignacio Sanz and Jim Oates and Keren Jakobi and Michelle Petri and Pennina Safer and Robert Gerwien and Rachel Sorek and Yakov Blumenstein and Cohen, {Irun R.}",
note = "Funding Information: The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115308 BIOVACSAFE, resources of which are composed of financial contributions from the European Union's Seventh Framework Programme ( FP7/2007-2013 ) and EFPIA companies in kind contribution. The Hopkins Lupus Cohort is supported by NIH RO-1 AR43727 . Funding Information: The authors wish to acknowledge the invaluable contributions of Ornit Cohen-Gindi, Miriam Lerner, Naama Shefer, Ilana Gilkaite, Angela Turner, Tim Van Meter, Justin Pitts, Joseph Green and Nazanin Mirshahi. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115308 BIOVACSAFE, resources of which are composed of financial contributions from the European Union''s Seventh Framework Programme (FP7/2007-2013) and EFPIA companies in kind contribution. The Hopkins Lupus Cohort is supported by NIH RO-1 AR43727. Publisher Copyright: {\textcopyright} 2015 Elsevier B.V.",
year = "2016",
month = feb,
day = "1",
doi = "10.1016/j.jim.2015.12.003",
language = "English (US)",
volume = "429",
pages = "1--6",
journal = "Journal of Immunological Methods",
issn = "0022-1759",
publisher = "Elsevier",
}