SLE-key® rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP®

Chaim Putterman, Alan Wu, Anat Reiner-Benaim, D. Scott Batty, Ignacio Sanz, Jim Oates, Keren Jakobi, Michelle Petri, Pennina Safer, Robert Gerwien, Rachel Sorek, Yakov Blumenstein, Irun R. Cohen

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

We describe here the development, verification and validation of the SLE-key® rule-out test for a definitive rule-out of a diagnosis of systemic lupus erythematosus (SLE). The test uses the proprietary iCHIP® micro-array technology platform (Fattal et al., 2010) to identify discriminating patterns of circulating autoantibodies among SLE patients compared with self-declared healthy individuals. Given the challenges associated with the diagnosis of SLE and the healthcare costs of delayed diagnosis and misdiagnosis, a definitive rule-out test can provide significant clinical benefits to patients and potentially major cost savings to healthcare systems.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalJournal of Immunological Methods
Volume429
DOIs
StatePublished - Feb 1 2016

Keywords

  • Autoantibodies
  • Diagnosis
  • ICHIP
  • Microarray
  • Multivariate classifier
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Putterman, C., Wu, A., Reiner-Benaim, A., Batty, D. S., Sanz, I., Oates, J., Jakobi, K., Petri, M., Safer, P., Gerwien, R., Sorek, R., Blumenstein, Y., & Cohen, I. R. (2016). SLE-key® rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP®. Journal of Immunological Methods, 429, 1-6. https://doi.org/10.1016/j.jim.2015.12.003