Site-specific effects of local pH changes in the substantia nigra pars reticulata on flurothyl-induced seizures

Libor Velíšek, Jana Velíšková, Solomon L. Moshé

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Local cerebral changes of acid-base balance may interfere with neuronal communication. Acidosis enhances and alkalosis suppresses GABA(A) receptor neurotransmission while there are opposite effects on NMDA receptor transmission. In this study, we determined site-specific effects of acidified solutions of Na-HEPES-artificial cerebrospinal fluid infused into the anterior or posterior area of the substantia nigra pars reticulata (SNR) in rats. Two levels of pH were compared: 6.7 and 7.4. Rats were challenged with flurothyl and the threshold for clonic and tonic-clonic seizures was determined. In the anterior SNR, there were no differences between the effects of the solution with pH 6.7 and 7.4 on flurothyl seizures. In contrast in the posterior SNR, microinfusions with pH 6.7 had proconvulsant effects. The results suggest that local pH changes may have site-specific effects on seizure susceptibility in vivo.

Original languageEnglish (US)
Pages (from-to)310-313
Number of pages4
JournalBrain research
Volume782
Issue number1-2
DOIs
Publication statusPublished - Jan 26 1998

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Keywords

  • Acidosis
  • Rat
  • Seizure susceptibility
  • Substantia nigra

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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