Site-specific effects of local pH changes in the substantia nigra pars reticulata on flurothyl-induced seizures

Libor Velíšek, Jana Velíšková, Solomon L. Moshe

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Local cerebral changes of acid-base balance may interfere with neuronal communication. Acidosis enhances and alkalosis suppresses GABA(A) receptor neurotransmission while there are opposite effects on NMDA receptor transmission. In this study, we determined site-specific effects of acidified solutions of Na-HEPES-artificial cerebrospinal fluid infused into the anterior or posterior area of the substantia nigra pars reticulata (SNR) in rats. Two levels of pH were compared: 6.7 and 7.4. Rats were challenged with flurothyl and the threshold for clonic and tonic-clonic seizures was determined. In the anterior SNR, there were no differences between the effects of the solution with pH 6.7 and 7.4 on flurothyl seizures. In contrast in the posterior SNR, microinfusions with pH 6.7 had proconvulsant effects. The results suggest that local pH changes may have site-specific effects on seizure susceptibility in vivo.

Original languageEnglish (US)
Pages (from-to)310-313
Number of pages4
JournalBrain Research
Volume782
Issue number1-2
DOIs
StatePublished - Jan 26 1998

Fingerprint

Flurothyl
Seizures
HEPES
Alkalosis
Acid-Base Equilibrium
GABA-A Receptors
Acidosis
N-Methyl-D-Aspartate Receptors
Synaptic Transmission
Cerebrospinal Fluid
Communication
Pars Reticulata

Keywords

  • Acidosis
  • Rat
  • Seizure susceptibility
  • Substantia nigra

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Site-specific effects of local pH changes in the substantia nigra pars reticulata on flurothyl-induced seizures. / Velíšek, Libor; Velíšková, Jana; Moshe, Solomon L.

In: Brain Research, Vol. 782, No. 1-2, 26.01.1998, p. 310-313.

Research output: Contribution to journalArticle

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