Sinusitis and atopy in human immunodeficiency virus infection

Catherine Butkus Small, Alan Kaufman, Melina Armenaka, David L. Rosenstreich

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Sinusitis is increased in patients with human immunodeficiency virus (HIV) infection. To determine the underlying mechanism(s), 37 HIV-positive patients were evaluated. HIV-negative controls included 21 with rhinosinusitis, 32 with atopy, and 16 without sinusitis. Twenty-two HIV-positive patients (59%) had sinusitis; 14 of them had AIDS. There was a significant association between sinusitis severity and stage of HIV infection (P < .05). IgE levels were higher in the HIV-positive patients, increased with disease progression, and were strongly correlated with sinusitis severity (P < .01). Of HIV-positive patients, 72% exhibited more than two positive skin tests compared with 24% of HIV-negative rhinosinusitis patients and 12.5% of controls (P < .05). Sinusitis is common in HIV-positive patients, especially those with AIDS. HIV causes an allergic diathesis with increased IgE levels and allergic reactivity. There is a significant correlation between IgE levels and sinusitis severity, suggesting sinusitis is part of this acquired atopic state. ,.

Original languageEnglish (US)
Pages (from-to)283-290
Number of pages8
JournalJournal of Infectious Diseases
Volume167
Issue number2
StatePublished - Feb 1993

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Sinusitis
Virus Diseases
HIV
Immunoglobulin E
Acquired Immunodeficiency Syndrome
Disease Susceptibility
Skin Tests
Disease Progression

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Sinusitis and atopy in human immunodeficiency virus infection. / Small, Catherine Butkus; Kaufman, Alan; Armenaka, Melina; Rosenstreich, David L.

In: Journal of Infectious Diseases, Vol. 167, No. 2, 02.1993, p. 283-290.

Research output: Contribution to journalArticle

Small, CB, Kaufman, A, Armenaka, M & Rosenstreich, DL 1993, 'Sinusitis and atopy in human immunodeficiency virus infection', Journal of Infectious Diseases, vol. 167, no. 2, pp. 283-290.
Small, Catherine Butkus ; Kaufman, Alan ; Armenaka, Melina ; Rosenstreich, David L. / Sinusitis and atopy in human immunodeficiency virus infection. In: Journal of Infectious Diseases. 1993 ; Vol. 167, No. 2. pp. 283-290.
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