Single-molecule insights into mRNA dynamics in neurons

Adina R. Buxbaum, Young J. Yoon, Robert H. Singer, Hye Yoon Park

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level.

Original languageEnglish (US)
Pages (from-to)468-475
Number of pages8
JournalTrends in Cell Biology
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2015

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Keywords

  • Local translation
  • RNA localization
  • mRNA tracking
  • smFISH

ASJC Scopus subject areas

  • Cell Biology

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