Silymarin downregulates COX-2 expression and attenuates hyperlipidemia during NDEA-induced rat hepatocellular carcinoma

Gopalakrishnan Ramakrishnan, Carmen Martha Elinos-Báez, Sundaram Jagan, Titto Alby Augustine, Sattu Kamaraj, Pandi Anandakumar, Thiruvengadam Devaki

Research output: Contribution to journalArticle

53 Scopus citations


Silymarin is a naturally available bioflavonoid and is a strong antioxidant with a capacity to inhibit the formation of tumors in several cancer models. In the present study, we investigated whether dietary supplementation of silymarin has any role in lipid components, lipid-metabolizing enzymes, free fatty acid profile, and expression of cyclooxygenase-2 (COX-2) in N-nitrosodiethylamine (NDEA)-induced hepatocellular carcinoma in rats. NDEA-induced rats showed severe hyperlipidemia along with upregulated expression of COX-2 as revealed by western blotting and immunohistochemistry. Dietary silymarin supplementation attenuated this hyperlipidemia and downregulated the expression of COX-2. Thus we conclude that compounds like silymarin with potent hypolipidemic effect are strong candidates as chemopreventive agents for the treatment of liver cancer.

Original languageEnglish (US)
Pages (from-to)53-61
Number of pages9
JournalMolecular and Cellular Biochemistry
Issue number1-2
StatePublished - Jun 1 2008
Externally publishedYes



  • COX-2
  • HMG-CoAreductase
  • Hepatocellular carcinoma
  • Hyperlipidemia
  • N-nitrosodiethylamine
  • Silymarin

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this