Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma

Vikas Mehta; Thomas J. Ow; Seokhwa Kim; Theresa Tharakan; Bradley Schiff; Richard V. Smith; Haejin In

doi:10.1002/hed.25596

Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma

Vikas Mehta, Thomas J. Ow, Seokhwa Kim, Theresa Tharakan, Bradley Schiff, Richard V. Smith, Haejin In

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Increased detection of papillary thyroid cancer (PTC) has led to overtreatment of the largely indolent follicular variant (fvPTC). To guide management of non-aggressive lesions, we investigated whether race predicts PTC variant and tumor behavior. Methods: Analysis of 258 973 patients from the National Cancer Database diagnosed with PTC in 2004-2014. Clinical and tumor information was compared by race. Multivariate logistic regression was used to predict fvPTC, extrathyroidal extension (ETE), and lymph node metastasis (LNM) of fvPTC. Results: Blacks had the highest fvPTC rate (40% vs white 30%, Hispanic 26%, Asian 25%, P <.001). Blacks had higher odds of fvPTC (aOR = 1.33, 95% CI: 1.28-1.37) and lower odds of ETE than whites (aOR = 0.90, 95% CI: 0.82-0.99) (P <.001). Hispanics and Asians had lower odds of fvPTC (aOR = 0.89, 95% CI: 0.86-0.92 and aOR = 0.81, 95% CI: 0.79-0.84) and higher odds of LNM and ETE than whites (P <.001). Conclusions: Racial disparities in fvPTC incidence and behavior should be considered to optimize diagnosis and treatment planning.

Original language	English (US)
Pages (from-to)	1403-1411
Number of pages	9
Journal	Head and Neck
Volume	41
Issue number	5
DOIs	https://doi.org/10.1002/hed.25596
State	Published - May 2019

Keywords

endocrine gland neoplasms
follicular variant
histologic variants
papillary thyroid cancer
thyroid cancer

ASJC Scopus subject areas

Otorhinolaryngology

Access to Document

10.1002/hed.25596

Fingerprint Dive into the research topics of 'Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma'. Together they form a unique fingerprint.

Cite this

@article{32f46e2f6b0a48cfb14acabb6b963360,

title = "Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma",

abstract = "Background: Increased detection of papillary thyroid cancer (PTC) has led to overtreatment of the largely indolent follicular variant (fvPTC). To guide management of non-aggressive lesions, we investigated whether race predicts PTC variant and tumor behavior. Methods: Analysis of 258 973 patients from the National Cancer Database diagnosed with PTC in 2004-2014. Clinical and tumor information was compared by race. Multivariate logistic regression was used to predict fvPTC, extrathyroidal extension (ETE), and lymph node metastasis (LNM) of fvPTC. Results: Blacks had the highest fvPTC rate (40% vs white 30%, Hispanic 26%, Asian 25%, P <.001). Blacks had higher odds of fvPTC (aOR = 1.33, 95% CI: 1.28-1.37) and lower odds of ETE than whites (aOR = 0.90, 95% CI: 0.82-0.99) (P <.001). Hispanics and Asians had lower odds of fvPTC (aOR = 0.89, 95% CI: 0.86-0.92 and aOR = 0.81, 95% CI: 0.79-0.84) and higher odds of LNM and ETE than whites (P <.001). Conclusions: Racial disparities in fvPTC incidence and behavior should be considered to optimize diagnosis and treatment planning.",

keywords = "endocrine gland neoplasms, follicular variant, histologic variants, papillary thyroid cancer, thyroid cancer",

author = "Vikas Mehta and Ow, {Thomas J.} and Seokhwa Kim and Theresa Tharakan and Bradley Schiff and Smith, {Richard V.} and Haejin In",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = may,

doi = "10.1002/hed.25596",

language = "English (US)",

volume = "41",

pages = "1403--1411",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "5",

}

TY - JOUR

T1 - Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma

AU - Mehta, Vikas

AU - Ow, Thomas J.

AU - Kim, Seokhwa

AU - Tharakan, Theresa

AU - Schiff, Bradley

AU - Smith, Richard V.

AU - In, Haejin

PY - 2019/5

Y1 - 2019/5

N2 - Background: Increased detection of papillary thyroid cancer (PTC) has led to overtreatment of the largely indolent follicular variant (fvPTC). To guide management of non-aggressive lesions, we investigated whether race predicts PTC variant and tumor behavior. Methods: Analysis of 258 973 patients from the National Cancer Database diagnosed with PTC in 2004-2014. Clinical and tumor information was compared by race. Multivariate logistic regression was used to predict fvPTC, extrathyroidal extension (ETE), and lymph node metastasis (LNM) of fvPTC. Results: Blacks had the highest fvPTC rate (40% vs white 30%, Hispanic 26%, Asian 25%, P <.001). Blacks had higher odds of fvPTC (aOR = 1.33, 95% CI: 1.28-1.37) and lower odds of ETE than whites (aOR = 0.90, 95% CI: 0.82-0.99) (P <.001). Hispanics and Asians had lower odds of fvPTC (aOR = 0.89, 95% CI: 0.86-0.92 and aOR = 0.81, 95% CI: 0.79-0.84) and higher odds of LNM and ETE than whites (P <.001). Conclusions: Racial disparities in fvPTC incidence and behavior should be considered to optimize diagnosis and treatment planning.

AB - Background: Increased detection of papillary thyroid cancer (PTC) has led to overtreatment of the largely indolent follicular variant (fvPTC). To guide management of non-aggressive lesions, we investigated whether race predicts PTC variant and tumor behavior. Methods: Analysis of 258 973 patients from the National Cancer Database diagnosed with PTC in 2004-2014. Clinical and tumor information was compared by race. Multivariate logistic regression was used to predict fvPTC, extrathyroidal extension (ETE), and lymph node metastasis (LNM) of fvPTC. Results: Blacks had the highest fvPTC rate (40% vs white 30%, Hispanic 26%, Asian 25%, P <.001). Blacks had higher odds of fvPTC (aOR = 1.33, 95% CI: 1.28-1.37) and lower odds of ETE than whites (aOR = 0.90, 95% CI: 0.82-0.99) (P <.001). Hispanics and Asians had lower odds of fvPTC (aOR = 0.89, 95% CI: 0.86-0.92 and aOR = 0.81, 95% CI: 0.79-0.84) and higher odds of LNM and ETE than whites (P <.001). Conclusions: Racial disparities in fvPTC incidence and behavior should be considered to optimize diagnosis and treatment planning.

KW - endocrine gland neoplasms

KW - follicular variant

KW - histologic variants

KW - papillary thyroid cancer

KW - thyroid cancer

UR - http://www.scopus.com/inward/record.url?scp=85060152312&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060152312&partnerID=8YFLogxK

U2 - 10.1002/hed.25596

DO - 10.1002/hed.25596

M3 - Article

C2 - 30652370

AN - SCOPUS:85060152312

VL - 41

SP - 1403

EP - 1411

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 5

ER -

Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this