Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma

Vikas Mehta, Thomas J. Ow, Seokhwa Kim, Theresa Tharakan, Bradley Schiff, Richard V. Smith, Haejin In

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Increased detection of papillary thyroid cancer (PTC) has led to overtreatment of the largely indolent follicular variant (fvPTC). To guide management of non-aggressive lesions, we investigated whether race predicts PTC variant and tumor behavior. Methods: Analysis of 258 973 patients from the National Cancer Database diagnosed with PTC in 2004-2014. Clinical and tumor information was compared by race. Multivariate logistic regression was used to predict fvPTC, extrathyroidal extension (ETE), and lymph node metastasis (LNM) of fvPTC. Results: Blacks had the highest fvPTC rate (40% vs white 30%, Hispanic 26%, Asian 25%, P <.001). Blacks had higher odds of fvPTC (aOR = 1.33, 95% CI: 1.28-1.37) and lower odds of ETE than whites (aOR = 0.90, 95% CI: 0.82-0.99) (P <.001). Hispanics and Asians had lower odds of fvPTC (aOR = 0.89, 95% CI: 0.86-0.92 and aOR = 0.81, 95% CI: 0.79-0.84) and higher odds of LNM and ETE than whites (P <.001). Conclusions: Racial disparities in fvPTC incidence and behavior should be considered to optimize diagnosis and treatment planning.

Original languageEnglish (US)
Pages (from-to)1403-1411
Number of pages9
JournalHead and Neck
Volume41
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • endocrine gland neoplasms
  • follicular variant
  • histologic variants
  • papillary thyroid cancer
  • thyroid cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

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