Abstract
Background: Increased detection of papillary thyroid cancer (PTC) has led to overtreatment of the largely indolent follicular variant (fvPTC). To guide management of non-aggressive lesions, we investigated whether race predicts PTC variant and tumor behavior. Methods: Analysis of 258 973 patients from the National Cancer Database diagnosed with PTC in 2004-2014. Clinical and tumor information was compared by race. Multivariate logistic regression was used to predict fvPTC, extrathyroidal extension (ETE), and lymph node metastasis (LNM) of fvPTC. Results: Blacks had the highest fvPTC rate (40% vs white 30%, Hispanic 26%, Asian 25%, P <.001). Blacks had higher odds of fvPTC (aOR = 1.33, 95% CI: 1.28-1.37) and lower odds of ETE than whites (aOR = 0.90, 95% CI: 0.82-0.99) (P <.001). Hispanics and Asians had lower odds of fvPTC (aOR = 0.89, 95% CI: 0.86-0.92 and aOR = 0.81, 95% CI: 0.79-0.84) and higher odds of LNM and ETE than whites (P <.001). Conclusions: Racial disparities in fvPTC incidence and behavior should be considered to optimize diagnosis and treatment planning.
| Original language | English (US) |
|---|---|
| Journal | Head and Neck |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
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Keywords
- endocrine gland neoplasms
- follicular variant
- histologic variants
- papillary thyroid cancer
- thyroid cancer
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma. / Mehta, Vikas; Ow, Thomas J.; Kim, Seokhwa; Tharakan, Theresa; Schiff, Bradley A.; Smith, Richard V.; In, Haejin.
In: Head and Neck, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Significant racial differences in the incidence and behavior of the follicular variant of papillary thyroid carcinoma
AU - Mehta, Vikas
AU - Ow, Thomas J.
AU - Kim, Seokhwa
AU - Tharakan, Theresa
AU - Schiff, Bradley A.
AU - Smith, Richard V.
AU - In, Haejin
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Increased detection of papillary thyroid cancer (PTC) has led to overtreatment of the largely indolent follicular variant (fvPTC). To guide management of non-aggressive lesions, we investigated whether race predicts PTC variant and tumor behavior. Methods: Analysis of 258 973 patients from the National Cancer Database diagnosed with PTC in 2004-2014. Clinical and tumor information was compared by race. Multivariate logistic regression was used to predict fvPTC, extrathyroidal extension (ETE), and lymph node metastasis (LNM) of fvPTC. Results: Blacks had the highest fvPTC rate (40% vs white 30%, Hispanic 26%, Asian 25%, P <.001). Blacks had higher odds of fvPTC (aOR = 1.33, 95% CI: 1.28-1.37) and lower odds of ETE than whites (aOR = 0.90, 95% CI: 0.82-0.99) (P <.001). Hispanics and Asians had lower odds of fvPTC (aOR = 0.89, 95% CI: 0.86-0.92 and aOR = 0.81, 95% CI: 0.79-0.84) and higher odds of LNM and ETE than whites (P <.001). Conclusions: Racial disparities in fvPTC incidence and behavior should be considered to optimize diagnosis and treatment planning.
AB - Background: Increased detection of papillary thyroid cancer (PTC) has led to overtreatment of the largely indolent follicular variant (fvPTC). To guide management of non-aggressive lesions, we investigated whether race predicts PTC variant and tumor behavior. Methods: Analysis of 258 973 patients from the National Cancer Database diagnosed with PTC in 2004-2014. Clinical and tumor information was compared by race. Multivariate logistic regression was used to predict fvPTC, extrathyroidal extension (ETE), and lymph node metastasis (LNM) of fvPTC. Results: Blacks had the highest fvPTC rate (40% vs white 30%, Hispanic 26%, Asian 25%, P <.001). Blacks had higher odds of fvPTC (aOR = 1.33, 95% CI: 1.28-1.37) and lower odds of ETE than whites (aOR = 0.90, 95% CI: 0.82-0.99) (P <.001). Hispanics and Asians had lower odds of fvPTC (aOR = 0.89, 95% CI: 0.86-0.92 and aOR = 0.81, 95% CI: 0.79-0.84) and higher odds of LNM and ETE than whites (P <.001). Conclusions: Racial disparities in fvPTC incidence and behavior should be considered to optimize diagnosis and treatment planning.
KW - endocrine gland neoplasms
KW - follicular variant
KW - histologic variants
KW - papillary thyroid cancer
KW - thyroid cancer
UR - http://www.scopus.com/inward/record.url?scp=85060152312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060152312&partnerID=8YFLogxK
U2 - 10.1002/hed.25596
DO - 10.1002/hed.25596
M3 - Article
C2 - 30652370
AN - SCOPUS:85060152312
JO - Head and Neck
JF - Head and Neck
SN - 1043-3074
ER -