Signaling networks regulating leukocyte podosome dynamics and function

Athanassios Dovas, Dianne Cox

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Podosomes are ventral adhesion structures prominent in cells of the myeloid lineage. A common aspect of these cells is that they are highly motile and must to traverse multiple tissue barriers in order to perform their functions. Recently podosomes have gathered attention from researchers as important cellular structures that can influence cell adhesion, motility and matrix remodeling. Adhesive and soluble ligands act via transmembrane receptors and propagate signals to the leukocyte cytoskeleton via small G proteins of the Rho family, tyrosine kinases and scaffold proteins and are able to induce podosome formation and rearrangements. Manipulation of the signals that regulate podosome formation and dynamics can therefore be a strategy to interfere with leukocyte functions in a multitude of pathological settings, such as infections, atherosclerosis and arthritis. Here, we review the major signaling molecules that act in the formation and regulation of podosomes.

Original languageEnglish (US)
Pages (from-to)1225-1234
Number of pages10
JournalCellular Signalling
Volume23
Issue number8
DOIs
StatePublished - Aug 1 2011

Keywords

  • Leukocyte
  • Podosome
  • Rho GTPase
  • Transmembrane receptor
  • Tyrosine kinase

ASJC Scopus subject areas

  • Cell Biology

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