Sickle cell anemia and comorbid leg ulcer treated with curative peripheral blood stem cell transplantation

Joseph L. Connor, Caterina P. Minniti, John F. Tisdale, Matthew M. Hsieh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Allogeneic bone marrow transplantation or peripheral blood stem cell transplantation (PBSCT) are the only curative therapies for patients with sickle cell disease (SCD). Once the patients have successfully undergone transplantation and engrafted, the hallmark of hemolytic anemia resolves, and normal hemoglobin levels are achieved. Some transplant protocols exclude patients with open wounds, including leg ulcers, because of infection risks associated with transplantation and long-term immunosuppression required to prevent graft-versus-host disease. Recalcitrant and recurrent leg ulcers are a serious complication of SCD and a determinant of morbidity. Here, we report the case of a 37-year-old man with sickle cell anemia and a chronic leg ulcer, who underwent PBSCT, engrafted successfully, and then had complete healing of his ulcer 16 months posttransplant.

Original languageEnglish (US)
Pages (from-to)56-59
Number of pages4
JournalInternational Journal of Lower Extremity Wounds
Volume16
Issue number1
DOIs
StatePublished - 2017

Fingerprint

Peripheral Blood Stem Cell Transplantation
Leg Ulcer
Sickle Cell Anemia
Transplantation
Hemolytic Anemia
Homologous Transplantation
Graft vs Host Disease
Bone Marrow Transplantation
Immunosuppression
Ulcer
Hemoglobins
Morbidity
Transplants
Wounds and Injuries
Infection
Therapeutics

Keywords

  • Immunosuppression
  • Leg ulcer
  • Nonmyeloablative
  • Sickle cell
  • Sirolimus
  • Stem cell transplant

ASJC Scopus subject areas

  • Surgery

Cite this

Sickle cell anemia and comorbid leg ulcer treated with curative peripheral blood stem cell transplantation. / Connor, Joseph L.; Minniti, Caterina P.; Tisdale, John F.; Hsieh, Matthew M.

In: International Journal of Lower Extremity Wounds, Vol. 16, No. 1, 2017, p. 56-59.

Research output: Contribution to journalArticle

@article{3f3a773d12d74dcfbc1f473d71432173,
title = "Sickle cell anemia and comorbid leg ulcer treated with curative peripheral blood stem cell transplantation",
abstract = "Allogeneic bone marrow transplantation or peripheral blood stem cell transplantation (PBSCT) are the only curative therapies for patients with sickle cell disease (SCD). Once the patients have successfully undergone transplantation and engrafted, the hallmark of hemolytic anemia resolves, and normal hemoglobin levels are achieved. Some transplant protocols exclude patients with open wounds, including leg ulcers, because of infection risks associated with transplantation and long-term immunosuppression required to prevent graft-versus-host disease. Recalcitrant and recurrent leg ulcers are a serious complication of SCD and a determinant of morbidity. Here, we report the case of a 37-year-old man with sickle cell anemia and a chronic leg ulcer, who underwent PBSCT, engrafted successfully, and then had complete healing of his ulcer 16 months posttransplant.",
keywords = "Immunosuppression, Leg ulcer, Nonmyeloablative, Sickle cell, Sirolimus, Stem cell transplant",
author = "Connor, {Joseph L.} and Minniti, {Caterina P.} and Tisdale, {John F.} and Hsieh, {Matthew M.}",
year = "2017",
doi = "10.1177/1534734616685636",
language = "English (US)",
volume = "16",
pages = "56--59",
journal = "International Journal of Lower Extremity Wounds",
issn = "1534-7346",
publisher = "SAGE Publications Inc.",
number = "1",

}

TY - JOUR

T1 - Sickle cell anemia and comorbid leg ulcer treated with curative peripheral blood stem cell transplantation

AU - Connor, Joseph L.

AU - Minniti, Caterina P.

AU - Tisdale, John F.

AU - Hsieh, Matthew M.

PY - 2017

Y1 - 2017

N2 - Allogeneic bone marrow transplantation or peripheral blood stem cell transplantation (PBSCT) are the only curative therapies for patients with sickle cell disease (SCD). Once the patients have successfully undergone transplantation and engrafted, the hallmark of hemolytic anemia resolves, and normal hemoglobin levels are achieved. Some transplant protocols exclude patients with open wounds, including leg ulcers, because of infection risks associated with transplantation and long-term immunosuppression required to prevent graft-versus-host disease. Recalcitrant and recurrent leg ulcers are a serious complication of SCD and a determinant of morbidity. Here, we report the case of a 37-year-old man with sickle cell anemia and a chronic leg ulcer, who underwent PBSCT, engrafted successfully, and then had complete healing of his ulcer 16 months posttransplant.

AB - Allogeneic bone marrow transplantation or peripheral blood stem cell transplantation (PBSCT) are the only curative therapies for patients with sickle cell disease (SCD). Once the patients have successfully undergone transplantation and engrafted, the hallmark of hemolytic anemia resolves, and normal hemoglobin levels are achieved. Some transplant protocols exclude patients with open wounds, including leg ulcers, because of infection risks associated with transplantation and long-term immunosuppression required to prevent graft-versus-host disease. Recalcitrant and recurrent leg ulcers are a serious complication of SCD and a determinant of morbidity. Here, we report the case of a 37-year-old man with sickle cell anemia and a chronic leg ulcer, who underwent PBSCT, engrafted successfully, and then had complete healing of his ulcer 16 months posttransplant.

KW - Immunosuppression

KW - Leg ulcer

KW - Nonmyeloablative

KW - Sickle cell

KW - Sirolimus

KW - Stem cell transplant

UR - http://www.scopus.com/inward/record.url?scp=85018176153&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018176153&partnerID=8YFLogxK

U2 - 10.1177/1534734616685636

DO - 10.1177/1534734616685636

M3 - Article

VL - 16

SP - 56

EP - 59

JO - International Journal of Lower Extremity Wounds

JF - International Journal of Lower Extremity Wounds

SN - 1534-7346

IS - 1

ER -