SGK1 is a critical component of an AKT-independent pathway essential for PI3K-mediated tumor development and maintenance

Arturo Orlacchio, Michela Ranieri, Martina Brave, Valeria Antico Arciuch, Toni Forde, Daniela De Martino, Karen E. Anderson, Phillip Hawkins, Antonio Di Cristofano

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Activation of the PI3K–AKT signaling cascade is a common critical event during malignant transformation. In this study, we used thyroid gland epithelial cells and a series of genetically engineered mouse strains as model systems to demonstrate that, although necessary, AKT activation is not sufficient for PI3K-driven transformation. Instead, transformation requires the activity of the PDK1-regulated AGC family of protein kinases. In particular, SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations. Notably, cotargeting SGK1 and AKT resulted in significantly higher growth suppression than inhibiting either PI3K or AKT alone. Overall, these findings underscore the clinical relevance of AKT-independent pathways in tumors driven by genetic lesions targeting the PI3K cascade.

Original languageEnglish (US)
Pages (from-to)6914-6926
Number of pages13
JournalCancer Research
Volume77
Issue number24
DOIs
StatePublished - Dec 15 2017

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Orlacchio, A., Ranieri, M., Brave, M., Arciuch, V. A., Forde, T., De Martino, D., Anderson, K. E., Hawkins, P., & Di Cristofano, A. (2017). SGK1 is a critical component of an AKT-independent pathway essential for PI3K-mediated tumor development and maintenance. Cancer Research, 77(24), 6914-6926. https://doi.org/10.1158/0008-5472.CAN-17-2105