Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease

Joanna A. Ruszkiewicz, Antonio Miranda-Vizuete, Alexey A. Tinkov, Margarita G. Skalnaya, Anatoly V. Skalny, Aristides Tsatsakis, Michael Aschner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sex differences in brain physiology and by inference various pathologies are generally recognized, however frequently ignored in epidemiological and experimental studies, leading to numerous data gaps. As a consequence, the mechanisms underlying sexual dimorphism of neurological diseases remain largely unknown. Several cellular and molecular pathways linked to the etiology and pathogenesis of various brain disorders have been recently described as sex-specific. Here, we review the evidence for sex differences in brain redox homeostasis, which is an important factor in brain physiology and disease. First, we focus on sex-specific differences in the healthy brain regarding popular redox balance markers, including reactive oxygen and nitrogen species, oxidative damage, and antioxidant status. We also review the modulatory effect of steroid sex hormones on these markers. Lastly, we approach the sex-specific changes in brain redox homeostasis in disease and discuss the possibility that differential redox response contributes to the sexual dimorphism of neurological disorders.

Original languageEnglish (US)
JournalJournal of Molecular Neuroscience
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Brain Diseases
Sex Characteristics
Oxidation-Reduction
Homeostasis
Brain
Reactive Nitrogen Species
Gonadal Steroid Hormones
Nervous System Diseases
Epidemiologic Studies
Reactive Oxygen Species
Antioxidants
Pathology

Keywords

  • Antioxidant
  • Brain
  • Neurodegeneration
  • Neurotoxicity
  • Oxidative stress
  • Sex

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Ruszkiewicz, J. A., Miranda-Vizuete, A., Tinkov, A. A., Skalnaya, M. G., Skalny, A. V., Tsatsakis, A., & Aschner, M. (Accepted/In press). Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease. Journal of Molecular Neuroscience. https://doi.org/10.1007/s12031-018-1241-9

Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease. / Ruszkiewicz, Joanna A.; Miranda-Vizuete, Antonio; Tinkov, Alexey A.; Skalnaya, Margarita G.; Skalny, Anatoly V.; Tsatsakis, Aristides; Aschner, Michael.

In: Journal of Molecular Neuroscience, 01.01.2019.

Research output: Contribution to journalArticle

Ruszkiewicz JA, Miranda-Vizuete A, Tinkov AA, Skalnaya MG, Skalny AV, Tsatsakis A et al. Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease. Journal of Molecular Neuroscience. 2019 Jan 1. https://doi.org/10.1007/s12031-018-1241-9
Ruszkiewicz, Joanna A. ; Miranda-Vizuete, Antonio ; Tinkov, Alexey A. ; Skalnaya, Margarita G. ; Skalny, Anatoly V. ; Tsatsakis, Aristides ; Aschner, Michael. / Sex-Specific Differences in Redox Homeostasis in Brain Norm and Disease. In: Journal of Molecular Neuroscience. 2019.
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