Serum immunoglobulins and IgG subclass levels in adults with chronic sinusitis: Evidence for decreased IgG3 levels

M. Armenaka, J. Grizzanti, David L. Rosenstreich

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Serum immunoglobulin class and IgG subclasses were measured in 30 adult patients with chronic sinusitis documented by CT scans of the paranasal sinuses. Results were compared to 30 age-and-sex matched patients with chronic rhinitis who had normal sinus CT scans, and a matched group of asymptomatic, healthy subjects. None of the patients was taking oral corticosteroids and none had ever received allergen immunotherapy. IgA deficiency was present in 3% (2/60) of the patients with chronic rhinitis or sinusitis and IgG deficiency was seen in another two (3%). None of the normals had low IgA or IgG. Low levels of IgG1 or IgG3 were found in some patients in all three groups, while none had low IgG2 levels. Serum levels of IgG, IgA, IgM, IgG1, IgG2, and IgG4 were not significantly different between the groups. Mean serum IgG3 levels, however, were significantly lower in the chronic sinusitis group than the chronic rhinitis group (P < .003) or the normals (P < .0005). The incidence of below normal levels of IgG3 was also more frequent in chronic sinusitis than in chronic rhinitis (P < .04) or normals (P < .002). Patients in the chronic sinusitis group had a high incidence of asthma (57%) and atopy (45%) but there was no difference in immunoglobulin class or IgG subclass levels in matched asthmatics compared with nonasthmatic patients with chronic sinusitis. Atopic patients with chronic sinusitis had a higher frequency of IgG3 subclass deficiency than nonatopics (P = .04). Normalization of low immunoglobulin class or IgG subclass levels that coincided with clinical improvement was documented in two patients with sinusitis. These findings indicate that IgG3 levels are significantly decreased in adults with chronic sinusitis independent of oral corticosteroid use. This may be a secondary phenomenon since low IgG3 levels may normalize with time.

Original languageEnglish (US)
Pages (from-to)507-514
Number of pages8
JournalAnnals of Allergy
Volume72
Issue number6
StatePublished - 1994

Fingerprint

Sinusitis
Immunoglobulins
Immunoglobulin G
Serum
Rhinitis
Immunoglobulin Isotypes
Immunoglobulin A
Adrenal Cortex Hormones
IgG Deficiency
IgA Deficiency
Immunologic Desensitization
Paranasal Sinuses
Incidence

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Serum immunoglobulins and IgG subclass levels in adults with chronic sinusitis : Evidence for decreased IgG3 levels. / Armenaka, M.; Grizzanti, J.; Rosenstreich, David L.

In: Annals of Allergy, Vol. 72, No. 6, 1994, p. 507-514.

Research output: Contribution to journalArticle

@article{c75fb6042ffe4ffdbe24986f0a2fd2aa,
title = "Serum immunoglobulins and IgG subclass levels in adults with chronic sinusitis: Evidence for decreased IgG3 levels",
abstract = "Serum immunoglobulin class and IgG subclasses were measured in 30 adult patients with chronic sinusitis documented by CT scans of the paranasal sinuses. Results were compared to 30 age-and-sex matched patients with chronic rhinitis who had normal sinus CT scans, and a matched group of asymptomatic, healthy subjects. None of the patients was taking oral corticosteroids and none had ever received allergen immunotherapy. IgA deficiency was present in 3{\%} (2/60) of the patients with chronic rhinitis or sinusitis and IgG deficiency was seen in another two (3{\%}). None of the normals had low IgA or IgG. Low levels of IgG1 or IgG3 were found in some patients in all three groups, while none had low IgG2 levels. Serum levels of IgG, IgA, IgM, IgG1, IgG2, and IgG4 were not significantly different between the groups. Mean serum IgG3 levels, however, were significantly lower in the chronic sinusitis group than the chronic rhinitis group (P < .003) or the normals (P < .0005). The incidence of below normal levels of IgG3 was also more frequent in chronic sinusitis than in chronic rhinitis (P < .04) or normals (P < .002). Patients in the chronic sinusitis group had a high incidence of asthma (57{\%}) and atopy (45{\%}) but there was no difference in immunoglobulin class or IgG subclass levels in matched asthmatics compared with nonasthmatic patients with chronic sinusitis. Atopic patients with chronic sinusitis had a higher frequency of IgG3 subclass deficiency than nonatopics (P = .04). Normalization of low immunoglobulin class or IgG subclass levels that coincided with clinical improvement was documented in two patients with sinusitis. These findings indicate that IgG3 levels are significantly decreased in adults with chronic sinusitis independent of oral corticosteroid use. This may be a secondary phenomenon since low IgG3 levels may normalize with time.",
author = "M. Armenaka and J. Grizzanti and Rosenstreich, {David L.}",
year = "1994",
language = "English (US)",
volume = "72",
pages = "507--514",
journal = "Annals of Allergy, Asthma and Immunology",
issn = "1081-1206",
publisher = "American College of Allergy, Asthma and Immunology",
number = "6",

}

TY - JOUR

T1 - Serum immunoglobulins and IgG subclass levels in adults with chronic sinusitis

T2 - Evidence for decreased IgG3 levels

AU - Armenaka, M.

AU - Grizzanti, J.

AU - Rosenstreich, David L.

PY - 1994

Y1 - 1994

N2 - Serum immunoglobulin class and IgG subclasses were measured in 30 adult patients with chronic sinusitis documented by CT scans of the paranasal sinuses. Results were compared to 30 age-and-sex matched patients with chronic rhinitis who had normal sinus CT scans, and a matched group of asymptomatic, healthy subjects. None of the patients was taking oral corticosteroids and none had ever received allergen immunotherapy. IgA deficiency was present in 3% (2/60) of the patients with chronic rhinitis or sinusitis and IgG deficiency was seen in another two (3%). None of the normals had low IgA or IgG. Low levels of IgG1 or IgG3 were found in some patients in all three groups, while none had low IgG2 levels. Serum levels of IgG, IgA, IgM, IgG1, IgG2, and IgG4 were not significantly different between the groups. Mean serum IgG3 levels, however, were significantly lower in the chronic sinusitis group than the chronic rhinitis group (P < .003) or the normals (P < .0005). The incidence of below normal levels of IgG3 was also more frequent in chronic sinusitis than in chronic rhinitis (P < .04) or normals (P < .002). Patients in the chronic sinusitis group had a high incidence of asthma (57%) and atopy (45%) but there was no difference in immunoglobulin class or IgG subclass levels in matched asthmatics compared with nonasthmatic patients with chronic sinusitis. Atopic patients with chronic sinusitis had a higher frequency of IgG3 subclass deficiency than nonatopics (P = .04). Normalization of low immunoglobulin class or IgG subclass levels that coincided with clinical improvement was documented in two patients with sinusitis. These findings indicate that IgG3 levels are significantly decreased in adults with chronic sinusitis independent of oral corticosteroid use. This may be a secondary phenomenon since low IgG3 levels may normalize with time.

AB - Serum immunoglobulin class and IgG subclasses were measured in 30 adult patients with chronic sinusitis documented by CT scans of the paranasal sinuses. Results were compared to 30 age-and-sex matched patients with chronic rhinitis who had normal sinus CT scans, and a matched group of asymptomatic, healthy subjects. None of the patients was taking oral corticosteroids and none had ever received allergen immunotherapy. IgA deficiency was present in 3% (2/60) of the patients with chronic rhinitis or sinusitis and IgG deficiency was seen in another two (3%). None of the normals had low IgA or IgG. Low levels of IgG1 or IgG3 were found in some patients in all three groups, while none had low IgG2 levels. Serum levels of IgG, IgA, IgM, IgG1, IgG2, and IgG4 were not significantly different between the groups. Mean serum IgG3 levels, however, were significantly lower in the chronic sinusitis group than the chronic rhinitis group (P < .003) or the normals (P < .0005). The incidence of below normal levels of IgG3 was also more frequent in chronic sinusitis than in chronic rhinitis (P < .04) or normals (P < .002). Patients in the chronic sinusitis group had a high incidence of asthma (57%) and atopy (45%) but there was no difference in immunoglobulin class or IgG subclass levels in matched asthmatics compared with nonasthmatic patients with chronic sinusitis. Atopic patients with chronic sinusitis had a higher frequency of IgG3 subclass deficiency than nonatopics (P = .04). Normalization of low immunoglobulin class or IgG subclass levels that coincided with clinical improvement was documented in two patients with sinusitis. These findings indicate that IgG3 levels are significantly decreased in adults with chronic sinusitis independent of oral corticosteroid use. This may be a secondary phenomenon since low IgG3 levels may normalize with time.

UR - http://www.scopus.com/inward/record.url?scp=0028332892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028332892&partnerID=8YFLogxK

M3 - Article

C2 - 8203794

AN - SCOPUS:0028332892

VL - 72

SP - 507

EP - 514

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

SN - 1081-1206

IS - 6

ER -