Serum biomarkers of immune activation and subsequent risk of non-hodgkin b-cell lymphoma among hiv-infected women

Shehnaz K. Hussain, Nancy A. Hessol, Alexandra M. Levine, Elizabeth Crabb Breen, Kathryn Anastos, Mardge Cohen, Gypsyamber D'Souza, Deborah R. Gustafson, Sylvia Silver, Otoniel Martínez-Maza

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: There is increasing evidence that chronic immune activation predisposes to non-Hodgkin lymphoma (NHL). Whether this association exists among women representative of the current HIV epidemic in the United States who are at high risk of HIV-associated NHL (AIDS-NHL), remains to be determined. Methods: We conducted a nested case-control study within the Women's Interagency HIV Study with longitudinally collected risk factor data and sera. Cases were HIV-infected women with stored sera collected at three time-windows 3 to 5 years, 1 to 3 years, and 0 to 1 year before AIDS-NHL diagnosis (n = 22). Three to six HIV-infected controls, without AIDS-NHL, were matched to each case on age, race, CD4+ T-cell count, and study follow-up time (n = 78). ORs and 95% confidence intervals (CI) for the association between one unit increase in log-transformed biomarker levels and AIDS-NHL were computed using random effect multivariate logistic regression models. Results: Elevated levels of sCD27 (OR = 7.21; 95% CI, 2.62-19.88), sCD30 (OR = 2.64; 95% CI, 1.24-5.64), and CXCL13 (OR = 2.56; 95% CI, 1.32-4.96) were associated with subsequent diagnosis of AIDS-NHL overall. Elevated sCD23 was associated with a two to three-fold increased risk of AIDS-NHL in certain subgroups, whereas elevated interleukin 6was associated with a two-fold increased risk in the 0 to 1 year time-window, only. Conclusions: These findings support the hypothesis that chronic B-cell activation contributes to the development of AIDS-NHL in women.

Original languageEnglish (US)
Pages (from-to)2084-2093
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume22
Issue number11
DOIs
StatePublished - Nov 2013

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Non-Hodgkin's Lymphoma
Immune Sera
Lymphoma
Biomarkers
Acquired Immunodeficiency Syndrome
HIV
Confidence Intervals
Logistic Models
Interleukins
CD4 Lymphocyte Count
Serum
Case-Control Studies
B-Lymphocytes
T-Lymphocytes

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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Serum biomarkers of immune activation and subsequent risk of non-hodgkin b-cell lymphoma among hiv-infected women. / Hussain, Shehnaz K.; Hessol, Nancy A.; Levine, Alexandra M.; Breen, Elizabeth Crabb; Anastos, Kathryn; Cohen, Mardge; D'Souza, Gypsyamber; Gustafson, Deborah R.; Silver, Sylvia; Martínez-Maza, Otoniel.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 22, No. 11, 11.2013, p. 2084-2093.

Research output: Contribution to journalArticle

Hussain, SK, Hessol, NA, Levine, AM, Breen, EC, Anastos, K, Cohen, M, D'Souza, G, Gustafson, DR, Silver, S & Martínez-Maza, O 2013, 'Serum biomarkers of immune activation and subsequent risk of non-hodgkin b-cell lymphoma among hiv-infected women', Cancer Epidemiology Biomarkers and Prevention, vol. 22, no. 11, pp. 2084-2093. https://doi.org/10.1158/1055-9965.EPI-13-0614
Hussain, Shehnaz K. ; Hessol, Nancy A. ; Levine, Alexandra M. ; Breen, Elizabeth Crabb ; Anastos, Kathryn ; Cohen, Mardge ; D'Souza, Gypsyamber ; Gustafson, Deborah R. ; Silver, Sylvia ; Martínez-Maza, Otoniel. / Serum biomarkers of immune activation and subsequent risk of non-hodgkin b-cell lymphoma among hiv-infected women. In: Cancer Epidemiology Biomarkers and Prevention. 2013 ; Vol. 22, No. 11. pp. 2084-2093.
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abstract = "Background: There is increasing evidence that chronic immune activation predisposes to non-Hodgkin lymphoma (NHL). Whether this association exists among women representative of the current HIV epidemic in the United States who are at high risk of HIV-associated NHL (AIDS-NHL), remains to be determined. Methods: We conducted a nested case-control study within the Women's Interagency HIV Study with longitudinally collected risk factor data and sera. Cases were HIV-infected women with stored sera collected at three time-windows 3 to 5 years, 1 to 3 years, and 0 to 1 year before AIDS-NHL diagnosis (n = 22). Three to six HIV-infected controls, without AIDS-NHL, were matched to each case on age, race, CD4+ T-cell count, and study follow-up time (n = 78). ORs and 95{\%} confidence intervals (CI) for the association between one unit increase in log-transformed biomarker levels and AIDS-NHL were computed using random effect multivariate logistic regression models. Results: Elevated levels of sCD27 (OR = 7.21; 95{\%} CI, 2.62-19.88), sCD30 (OR = 2.64; 95{\%} CI, 1.24-5.64), and CXCL13 (OR = 2.56; 95{\%} CI, 1.32-4.96) were associated with subsequent diagnosis of AIDS-NHL overall. Elevated sCD23 was associated with a two to three-fold increased risk of AIDS-NHL in certain subgroups, whereas elevated interleukin 6was associated with a two-fold increased risk in the 0 to 1 year time-window, only. Conclusions: These findings support the hypothesis that chronic B-cell activation contributes to the development of AIDS-NHL in women.",
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T1 - Serum biomarkers of immune activation and subsequent risk of non-hodgkin b-cell lymphoma among hiv-infected women

AU - Hussain, Shehnaz K.

AU - Hessol, Nancy A.

AU - Levine, Alexandra M.

AU - Breen, Elizabeth Crabb

AU - Anastos, Kathryn

AU - Cohen, Mardge

AU - D'Souza, Gypsyamber

AU - Gustafson, Deborah R.

AU - Silver, Sylvia

AU - Martínez-Maza, Otoniel

PY - 2013/11

Y1 - 2013/11

N2 - Background: There is increasing evidence that chronic immune activation predisposes to non-Hodgkin lymphoma (NHL). Whether this association exists among women representative of the current HIV epidemic in the United States who are at high risk of HIV-associated NHL (AIDS-NHL), remains to be determined. Methods: We conducted a nested case-control study within the Women's Interagency HIV Study with longitudinally collected risk factor data and sera. Cases were HIV-infected women with stored sera collected at three time-windows 3 to 5 years, 1 to 3 years, and 0 to 1 year before AIDS-NHL diagnosis (n = 22). Three to six HIV-infected controls, without AIDS-NHL, were matched to each case on age, race, CD4+ T-cell count, and study follow-up time (n = 78). ORs and 95% confidence intervals (CI) for the association between one unit increase in log-transformed biomarker levels and AIDS-NHL were computed using random effect multivariate logistic regression models. Results: Elevated levels of sCD27 (OR = 7.21; 95% CI, 2.62-19.88), sCD30 (OR = 2.64; 95% CI, 1.24-5.64), and CXCL13 (OR = 2.56; 95% CI, 1.32-4.96) were associated with subsequent diagnosis of AIDS-NHL overall. Elevated sCD23 was associated with a two to three-fold increased risk of AIDS-NHL in certain subgroups, whereas elevated interleukin 6was associated with a two-fold increased risk in the 0 to 1 year time-window, only. Conclusions: These findings support the hypothesis that chronic B-cell activation contributes to the development of AIDS-NHL in women.

AB - Background: There is increasing evidence that chronic immune activation predisposes to non-Hodgkin lymphoma (NHL). Whether this association exists among women representative of the current HIV epidemic in the United States who are at high risk of HIV-associated NHL (AIDS-NHL), remains to be determined. Methods: We conducted a nested case-control study within the Women's Interagency HIV Study with longitudinally collected risk factor data and sera. Cases were HIV-infected women with stored sera collected at three time-windows 3 to 5 years, 1 to 3 years, and 0 to 1 year before AIDS-NHL diagnosis (n = 22). Three to six HIV-infected controls, without AIDS-NHL, were matched to each case on age, race, CD4+ T-cell count, and study follow-up time (n = 78). ORs and 95% confidence intervals (CI) for the association between one unit increase in log-transformed biomarker levels and AIDS-NHL were computed using random effect multivariate logistic regression models. Results: Elevated levels of sCD27 (OR = 7.21; 95% CI, 2.62-19.88), sCD30 (OR = 2.64; 95% CI, 1.24-5.64), and CXCL13 (OR = 2.56; 95% CI, 1.32-4.96) were associated with subsequent diagnosis of AIDS-NHL overall. Elevated sCD23 was associated with a two to three-fold increased risk of AIDS-NHL in certain subgroups, whereas elevated interleukin 6was associated with a two-fold increased risk in the 0 to 1 year time-window, only. Conclusions: These findings support the hypothesis that chronic B-cell activation contributes to the development of AIDS-NHL in women.

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