Serum androgen markers in preeclampsia

Nora R. Miller, David Garry, Hillel W. Cohen, Reinaldo Figueroa

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

OBJECTIVE: To determine whether maternal serum levels of androgens are associated with preeclampsia in primigravid women. STUDY DESIGN: A case-control study of primigravid women with singleton pregnancies. Women diagnosed with preeclampsia (n = 15) were matched with normotensive controls (n = 30) for age and gestational age. Serum testosterone, sex hormone binding globulin, estradiol and dehydroepiandrosterone sulfate were measured before delivery. The study had 80% power to detect a 30% difference in mean testosterone concentration between cases and controls using a two-tailed test and α level of .05. The Student t test, Mann-Whitney U test, Wilcoxon signed ranks test and χ 2 analysis of proportions were used for analysis. RESULTS: Cases and controls did not differ in maternal age, gestational age, body mass index, tobacco use or neonatal sex. As compared with normotensive controls, preeclamptic women exhibited no statistically significant differences in median levels of total testosterone, free androgen index, sex hormone binding globulin, estradiol or dehydroepiandrosterone sulfate. CONCLUSION: Maternal serum levels of androgens do not exhibit an association with preeclampsia in primigravid women.

Original languageEnglish (US)
Pages (from-to)225-229
Number of pages5
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume48
Issue number4
StatePublished - Apr 1 2003

Keywords

  • Androgens
  • Dehydroepiandrosterone sulfate
  • Pre-eclampsia
  • Sex hormone-binding globulin
  • Testosterone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Miller, N. R., Garry, D., Cohen, H. W., & Figueroa, R. (2003). Serum androgen markers in preeclampsia. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 48(4), 225-229.