Serotonergic function in social phobia: Comparison to normal control and obsessive-compulsive disorder subjects

Eric Hollander, Jee Kwon, Fenia Weiller, Lisa Cohen, Dan J. Stein, Concetta DeCaria, Michael Liebowitz, Daphne Simeon

Research output: Contribution to journalArticle

38 Scopus citations


Eighteen patients with social phobia, 21 normal control subjects, and 42 obsessive-compulsive disorder (OCD) control subjects were challenged with single doses of the partial serotonin agonist oral m-chlorophenylpiperazine (m-CPP) and placebo. Social phobics did not significantly differ from normal or OCD control subjects in prolactin response to m-CPP. There was a significant difference across groups in cortisol response to m-CPP, such that female social phobics had more robust cortisol responses to the m-CPP challenge. Pairwise comparisons only reached trend significance, perhaps due to the relatively small sample sizes. This study offers preliminary evidence for serotonin dysfunction in social phobia, particularly in female social phobics, but needs to be replicated in a larger sample size.

Original languageEnglish (US)
Pages (from-to)213-217
Number of pages5
JournalPsychiatry Research
Issue number3
Publication statusPublished - Jul 13 1998



  • Cortisol
  • Obsessive-compulsive disorder
  • Prolactin
  • Serotonin (5-HT)
  • Social phobia
  • m- CPP

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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