Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults

Mark H. Kuniholm, Nathan D. Wolfe, Claire Y H Huang, E. Mpoudi-Ngole, Ubald Tamoufe, Donald S. Burke, Duane J. Gubler

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Arboviruses from the families Flaviviridae, Togaviridae, and Bunyaviridae are suspected to cause widespread morbidity in sub-Saharan African populations, but little research been done to document the burden and distribution of these pathogens. We tested serum samples from 256 Cameroonian adults from nine rural villages for the presence of Dengue-2 (DEN-2), West Nile (WN), Yellow fever (YF), Chikungunya (CHIK), O'nyong-nyong (ONN), Sindbis (SIN), and Tahyna (TAH) infection using standard plaque-reduction neutralization tests (PRNT). Of these samples, 12.5% were DEN-2 positive, 6.6% were WN positive, 26.9% were YF positive, 46.5% were CHIK seropositive, 47.7% were ONN positive, 7.8% were SIN positive, and 36.3% were TAH positive. DEN-2, YF, and CHIK seroprevalence rates were lower among individuals living in dwellings with grass or thatched roofs versus corrugated tin and in villages isolated from urban centers. Seroprevalence rates of YF and CHIK increased with age. These results suggest that inter-epidemic arboviral infection is common in central African populations.

Original languageEnglish (US)
Pages (from-to)1078-1083
Number of pages6
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume74
Issue number6
StatePublished - Jun 2006
Externally publishedYes

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Bunyaviridae Infections
Togaviridae
Flaviviridae
Yellow Fever
Seroepidemiologic Studies
Dengue
West Nile Fever
Bunyaviridae
Arboviruses
Neutralization Tests
Tin
Poaceae
Infection
Population
Morbidity
Serum
Research

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Kuniholm, M. H., Wolfe, N. D., Huang, C. Y. H., Mpoudi-Ngole, E., Tamoufe, U., Burke, D. S., & Gubler, D. J. (2006). Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults. American Journal of Tropical Medicine and Hygiene, 74(6), 1078-1083.

Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults. / Kuniholm, Mark H.; Wolfe, Nathan D.; Huang, Claire Y H; Mpoudi-Ngole, E.; Tamoufe, Ubald; Burke, Donald S.; Gubler, Duane J.

In: American Journal of Tropical Medicine and Hygiene, Vol. 74, No. 6, 06.2006, p. 1078-1083.

Research output: Contribution to journalArticle

Kuniholm, MH, Wolfe, ND, Huang, CYH, Mpoudi-Ngole, E, Tamoufe, U, Burke, DS & Gubler, DJ 2006, 'Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults', American Journal of Tropical Medicine and Hygiene, vol. 74, no. 6, pp. 1078-1083.
Kuniholm, Mark H. ; Wolfe, Nathan D. ; Huang, Claire Y H ; Mpoudi-Ngole, E. ; Tamoufe, Ubald ; Burke, Donald S. ; Gubler, Duane J. / Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults. In: American Journal of Tropical Medicine and Hygiene. 2006 ; Vol. 74, No. 6. pp. 1078-1083.
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