Sequential occurrence of IgA nephropathy and Henoch-Schönlein purpura: support for common pathogenesis

Douglas M. Silverstein, Ira Greifer, Vaughn Folkert, Boyce Bennett, Howard E. Corey, Adrian Spitzer

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We report a patient who developed Henoch-Schönlein purpura (HSP) 13 years after he presented with IgA nephropathy (IgAN). In both HSP and IgAN renal biopsy most commonly reveals focal proliferative glomerulonephritis on light microscopy and immunofluorescence displays mesangial IgA deposits. In addition, patients with HSP or IgAN have elevated serum IgA levels, circulating IgA immune complexes, IgA-bearing lymphocytes, immunoglobulin-producing cells, and binding of IgG to glomerular components of similar molecular weight. The occurrence of both diseases in the same patient or the same families and the presence of immune abnormalities compatible with HSP or IgAN in relatives of patients with these diseases suggest a common pathogenesis.

Original languageEnglish (US)
Pages (from-to)752-753
Number of pages2
JournalPediatric Nephrology
Volume8
Issue number6
DOIs
StatePublished - Dec 1 1994

Keywords

  • Familial
  • Henoch-Schönlein purpura
  • IgA nephropathy
  • Immunological
  • Pathogenesis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

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    Silverstein, D. M., Greifer, I., Folkert, V., Bennett, B., Corey, H. E., & Spitzer, A. (1994). Sequential occurrence of IgA nephropathy and Henoch-Schönlein purpura: support for common pathogenesis. Pediatric Nephrology, 8(6), 752-753. https://doi.org/10.1007/BF00869111