Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer: Updated analysis of the observational GioTag study

Maximilian J. Hochmair; Alessandro Morabito; Desiree Hao; Cheng Ta Yang; Ross A. Soo; James C.H. Yang; Rasim Gucalp; Balazs Halmos; Lara Wang; Angela Märten; Tanja Cufer

doi:10.2217/fon-2019-0346

Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer: Updated analysis of the observational GioTag study

Maximilian J. Hochmair, Alessandro Morabito, Desiree Hao, Cheng Ta Yang, Ross A. Soo, James C.H. Yang, Rasim Gucalp, Balazs Halmos, Lara Wang, Angela Märten, Tanja Cufer

Medicine

Research output: Contribution to journal › Review article

12 Scopus citations

Abstract

Aims: Overall survival (OS) and updated time to treatment failure (TTF) analysis of patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer who received sequential afatinib/osimertinib in the real-world GioTag study. Patients & methods: Patients had T790M-positive disease following first-line afatinib and received osimertinib treatment (n = 203). Primary outcome was TTF. The OS analysis was exploratory. Results: Median OS was 41.3 months (90% CI: 36.8-46.3) overall and 45.7 months (90% CI: 45.3-51.5) in patients with Del19-positive tumors (n = 149); 2-year survival was 80 and 82%, respectively. Updated median TTF with afatinib and osimertinib was 28.1 months (90% CI: 26.8-30.3). Conclusion: Sequential afatinib/osimertinib was associated with encouraging OS/TTF in patients with EGFR T790M-positive non-small-cell lung cancer, especially in patients with Del19-positive tumors. Trial registration number: NCT0337077.

Original language	English (US)
Pages (from-to)	2905-2914
Number of pages	10
Journal	Future Oncology
Volume	15
Issue number	25
DOIs	https://doi.org/10.2217/fon-2019-0346
State	Published - Jan 1 2019

Keywords

NSCLC
T790M
afatinib
osimertinib
sequential

ASJC Scopus subject areas

Oncology
Cancer Research

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Hochmair, M. J., Morabito, A., Hao, D., Yang, C. T., Soo, R. A., Yang, J. C. H., Gucalp, R., Halmos, B., Wang, L., Märten, A., & Cufer, T. (2019). Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer: Updated analysis of the observational GioTag study. Future Oncology, 15(25), 2905-2914. https://doi.org/10.2217/fon-2019-0346

Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer : Updated analysis of the observational GioTag study. / Hochmair, Maximilian J.; Morabito, Alessandro; Hao, Desiree; Yang, Cheng Ta; Soo, Ross A.; Yang, James C.H.; Gucalp, Rasim ; Halmos, Balazs; Wang, Lara; Märten, Angela; Cufer, Tanja.

In: Future Oncology, Vol. 15, No. 25, 01.01.2019, p. 2905-2914.

Research output: Contribution to journal › Review article

Hochmair, Maximilian J. ; Morabito, Alessandro ; Hao, Desiree ; Yang, Cheng Ta ; Soo, Ross A. ; Yang, James C.H. ; Gucalp, Rasim ; Halmos, Balazs ; Wang, Lara ; Märten, Angela ; Cufer, Tanja. / Sequential afatinib and osimertinib in patients with EGFR mutation-positive non-small-cell lung cancer : Updated analysis of the observational GioTag study. In: Future Oncology. 2019 ; Vol. 15, No. 25. pp. 2905-2914.

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abstract = "Aims: Overall survival (OS) and updated time to treatment failure (TTF) analysis of patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer who received sequential afatinib/osimertinib in the real-world GioTag study. Patients & methods: Patients had T790M-positive disease following first-line afatinib and received osimertinib treatment (n = 203). Primary outcome was TTF. The OS analysis was exploratory. Results: Median OS was 41.3 months (90% CI: 36.8-46.3) overall and 45.7 months (90% CI: 45.3-51.5) in patients with Del19-positive tumors (n = 149); 2-year survival was 80 and 82%, respectively. Updated median TTF with afatinib and osimertinib was 28.1 months (90% CI: 26.8-30.3). Conclusion: Sequential afatinib/osimertinib was associated with encouraging OS/TTF in patients with EGFR T790M-positive non-small-cell lung cancer, especially in patients with Del19-positive tumors. Trial registration number: NCT0337077.",

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AB - Aims: Overall survival (OS) and updated time to treatment failure (TTF) analysis of patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer who received sequential afatinib/osimertinib in the real-world GioTag study. Patients & methods: Patients had T790M-positive disease following first-line afatinib and received osimertinib treatment (n = 203). Primary outcome was TTF. The OS analysis was exploratory. Results: Median OS was 41.3 months (90% CI: 36.8-46.3) overall and 45.7 months (90% CI: 45.3-51.5) in patients with Del19-positive tumors (n = 149); 2-year survival was 80 and 82%, respectively. Updated median TTF with afatinib and osimertinib was 28.1 months (90% CI: 26.8-30.3). Conclusion: Sequential afatinib/osimertinib was associated with encouraging OS/TTF in patients with EGFR T790M-positive non-small-cell lung cancer, especially in patients with Del19-positive tumors. Trial registration number: NCT0337077.

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