Selective inhibition of human glial inducible nitric oxide synthase by interferon-β

Implications for multiple sclerosis

Liwei L. Hua, Judy S H Liu, Celia F. Brosnan, Sunhee C. Lee

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Nitric oxide generated from the inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of multiple sclerosis. Because significant species- and cell-specific differences exist in the expression of iNOS, we used primary human glial cell cultures to screen for an inhibitor of iNOS expression. Remarkably, among numerous soluble factors tested, interferon-β (IFN-β) alone showed a selective and potent inhibition of interleukin-1β/interferon-γ (IL-1β/IFN-γ)-induced iNOS expression in astrocytes. Inhibition of iNOS may provide a mechanism by which IFN-β can ameliorate inflammation and cytotoxicity in the central nervous system of patients with multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)384-387
Number of pages4
JournalAnnals of Neurology
Volume43
Issue number3
DOIs
StatePublished - Mar 1998

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Nitric Oxide Synthase Type II
Neuroglia
Interferons
Multiple Sclerosis
Interleukin-1
Astrocytes
Nitric Oxide
Central Nervous System
Cell Culture Techniques
Inflammation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Selective inhibition of human glial inducible nitric oxide synthase by interferon-β : Implications for multiple sclerosis. / Hua, Liwei L.; Liu, Judy S H; Brosnan, Celia F.; Lee, Sunhee C.

In: Annals of Neurology, Vol. 43, No. 3, 03.1998, p. 384-387.

Research output: Contribution to journalArticle

Hua, Liwei L. ; Liu, Judy S H ; Brosnan, Celia F. ; Lee, Sunhee C. / Selective inhibition of human glial inducible nitric oxide synthase by interferon-β : Implications for multiple sclerosis. In: Annals of Neurology. 1998 ; Vol. 43, No. 3. pp. 384-387.
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