Seizures in the developing brain

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Clinical and animal data show that there is a period of increased susceptibility to seizures during early postnatal development. The cause of this increased susceptibility is probably a combination of enhanced excitation and diminished inhibition throughout the brain, as well as developmental differences in subcortical circuits, such as the substantia nigra-mediated seizure-suppression system. Animal studies on the effect of prolonged epileptic seizures early in development indicate that even severe seizures produce little or no damage in the rat pup hippocampus. Several studies have demonstrated both qualitative and quantitative age-dependent differences in the effect of antiepileptic treatment. More studies are needed to determine the effects of long-term antiepileptic treatment.

Original languageEnglish (US)
JournalNeurology
Volume43
Issue number11
StatePublished - 1993

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Seizures
Anticonvulsants
Brain
Substantia Nigra
Epilepsy
Hippocampus
Animals
Susceptibility

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Seizures in the developing brain. / Moshe, Solomon L.

In: Neurology, Vol. 43, No. 11, 1993.

Research output: Contribution to journalArticle

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