Seeking closure: How do herpesviruses recruit the cellular ESCRT apparatus?

Jenna Barnes, Duncan W. Wilson

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Herpesviridae are structurally complex DNA viruses whose capsids undergo primary envelopment at the inner nuclear membrane and secondary envelopment at organelles in the cytoplasm. In both locations, there is evidence that envelope formation and scission involve the participation of multiple viral proteins and also the cellular ESCRT apparatus. It nevertheless appears that the best-understood viral strategies for ESCRT recruitment, those adopted by the retroviruses and many other families of enveloped RNA viruses, are not utilized by the Herpesviridae, at least during envelopment in the cytoplasm. Thus, although a large number of herpesvirus proteins have been assigned roles in envelopment, there is a dearth of candidates for the acquisition of the ESCRT complex and the control of envelope scission. This review summarizes our current understanding of ESCRT association by enveloped viruses, examines what is known of herpesvirus ESCRT utilization in the nucleus and cytoplasm, and identifies candidate cellular and viral proteins that could link enveloping herpesviruses to cellular ESCRT components.

Original languageEnglish (US)
Article numbere00392-19
JournalJournal of virology
Volume93
Issue number13
DOIs
StatePublished - Jan 1 2019

Fingerprint

Herpesviridae
cytoplasm
viral proteins
Retroviridae
Cytoplasm
Viral Proteins
DNA viruses
capsid
nuclear membrane
Endosomal Sorting Complexes Required for Transport
organelles
DNA Viruses
Capsid
RNA Viruses
Nuclear Envelope
viruses
Organelles
Viruses
proteins
Proteins

Keywords

  • Envelopment
  • ESCRT
  • Herpesviridae

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Seeking closure : How do herpesviruses recruit the cellular ESCRT apparatus? / Barnes, Jenna; Wilson, Duncan W.

In: Journal of virology, Vol. 93, No. 13, e00392-19, 01.01.2019.

Research output: Contribution to journalArticle

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