Abstract
The Herpesviridae are structurally complex DNA viruses whose capsids undergo primary envelopment at the inner nuclear membrane and secondary envelopment at organelles in the cytoplasm. In both locations, there is evidence that envelope formation and scission involve the participation of multiple viral proteins and also the cellular ESCRT apparatus. It nevertheless appears that the best-understood viral strategies for ESCRT recruitment, those adopted by the retroviruses and many other families of enveloped RNA viruses, are not utilized by the Herpesviridae, at least during envelopment in the cytoplasm. Thus, although a large number of herpesvirus proteins have been assigned roles in envelopment, there is a dearth of candidates for the acquisition of the ESCRT complex and the control of envelope scission. This review summarizes our current understanding of ESCRT association by enveloped viruses, examines what is known of herpesvirus ESCRT utilization in the nucleus and cytoplasm, and identifies candidate cellular and viral proteins that could link enveloping herpesviruses to cellular ESCRT components.
| Original language | English (US) |
|---|---|
| Article number | e00392-19 |
| Journal | Journal of virology |
| Volume | 93 |
| Issue number | 13 |
| DOIs | |
| State | Published - Jan 1 2019 |
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Keywords
- Envelopment
- ESCRT
- Herpesviridae
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology
Cite this
Seeking closure : How do herpesviruses recruit the cellular ESCRT apparatus? / Barnes, Jenna; Wilson, Duncan W.
In: Journal of virology, Vol. 93, No. 13, e00392-19, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Seeking closure
T2 - How do herpesviruses recruit the cellular ESCRT apparatus?
AU - Barnes, Jenna
AU - Wilson, Duncan W.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - The Herpesviridae are structurally complex DNA viruses whose capsids undergo primary envelopment at the inner nuclear membrane and secondary envelopment at organelles in the cytoplasm. In both locations, there is evidence that envelope formation and scission involve the participation of multiple viral proteins and also the cellular ESCRT apparatus. It nevertheless appears that the best-understood viral strategies for ESCRT recruitment, those adopted by the retroviruses and many other families of enveloped RNA viruses, are not utilized by the Herpesviridae, at least during envelopment in the cytoplasm. Thus, although a large number of herpesvirus proteins have been assigned roles in envelopment, there is a dearth of candidates for the acquisition of the ESCRT complex and the control of envelope scission. This review summarizes our current understanding of ESCRT association by enveloped viruses, examines what is known of herpesvirus ESCRT utilization in the nucleus and cytoplasm, and identifies candidate cellular and viral proteins that could link enveloping herpesviruses to cellular ESCRT components.
AB - The Herpesviridae are structurally complex DNA viruses whose capsids undergo primary envelopment at the inner nuclear membrane and secondary envelopment at organelles in the cytoplasm. In both locations, there is evidence that envelope formation and scission involve the participation of multiple viral proteins and also the cellular ESCRT apparatus. It nevertheless appears that the best-understood viral strategies for ESCRT recruitment, those adopted by the retroviruses and many other families of enveloped RNA viruses, are not utilized by the Herpesviridae, at least during envelopment in the cytoplasm. Thus, although a large number of herpesvirus proteins have been assigned roles in envelopment, there is a dearth of candidates for the acquisition of the ESCRT complex and the control of envelope scission. This review summarizes our current understanding of ESCRT association by enveloped viruses, examines what is known of herpesvirus ESCRT utilization in the nucleus and cytoplasm, and identifies candidate cellular and viral proteins that could link enveloping herpesviruses to cellular ESCRT components.
KW - Envelopment
KW - ESCRT
KW - Herpesviridae
UR - http://www.scopus.com/inward/record.url?scp=85068179050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068179050&partnerID=8YFLogxK
U2 - 10.1128/JVI.00392-19
DO - 10.1128/JVI.00392-19
M3 - Article
C2 - 30996099
AN - SCOPUS:85068179050
VL - 93
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 13
M1 - e00392-19
ER -