Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: A case report and review of the literature

Chloe Goldman, Mathew J. Akiyama, Julian Torres, Eddie Louie, Shane A. Meehan

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. It poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. We present an immunocompromised patient with a cutaneous S. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. Adding echinocandins and GM-CSF provided partial recovery, indicating a potential synergistic role of dual-antifungal and immunotherapeutic agents.

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalMedical Mycology Case Reports
Volume11
DOIs
StatePublished - Mar 2016
Externally publishedYes

Keywords

  • Corticosteroid
  • GM-CSF
  • Immunocompromised
  • Scedosporium
  • Synergy

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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