Scedosporium apiospermum infections and the role of combination antifungal therapy and GM-CSF: A case report and review of the literature

Chloe Goldman, Matthew J. Akiyama, Julian A. Torres Isasiga, Eddie Louie, Shane A. Meehan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. It poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. We present an immunocompromised patient with a cutaneous S. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. Adding echinocandins and GM-CSF provided partial recovery, indicating a potential synergistic role of dual-antifungal and immunotherapeutic agents.

Original languageEnglish (US)
Pages (from-to)40-43
Number of pages4
JournalMedical Mycology Case Reports
Volume11
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

Fingerprint

Scedosporium
Immunocompromised Host
Granulocyte-Macrophage Colony-Stimulating Factor
Echinocandins
Mycoses
Antifungal Agents
Infection
Fungi
Skin
Therapeutics
Pharmaceutical Preparations

Keywords

  • Corticosteroid
  • GM-CSF
  • Immunocompromised
  • Scedosporium
  • Synergy

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology

Cite this

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AU - Meehan, Shane A.

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AB - Scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. It poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. We present an immunocompromised patient with a cutaneous S. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. Adding echinocandins and GM-CSF provided partial recovery, indicating a potential synergistic role of dual-antifungal and immunotherapeutic agents.

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