Sample size calculations for clustered and longitudinal outcomes in clinical research

Chul Ahn, Moonseong Heo, Song Zhang

Research output: Book/ReportBook

8 Citations (Scopus)

Abstract

Accurate sample size calculation ensures that clinical studies have adequate power to detect clinically meaningful effects. This results in the efficient use of resources and avoids exposing a disproportionate number of patients to experimental treatments caused by an overpowered study. Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research explains how to determine sample size for studies with correlated outcomes, which are widely implemented in medical, epidemiological, and behavioral studies. The book focuses on issues specific to the two types of correlated outcomes: longitudinal and clustered. For clustered studies, the authors provide sample size formulas that accommodate variable cluster sizes and within-cluster correlation. For longitudinal studies, they present sample size formulas to account for within-subject correlation among repeated measurements and various missing data patterns. For multiple levels of clustering, the level at which to perform randomization actually becomes a design parameter. The authors show how this can greatly impact trial administration, analysis, and sample size requirement. Addressing the overarching theme of sample size determination for correlated outcomes, this book provides a useful resource for biostatisticians, clinical investigators, epidemiologists, and social scientists whose research involves trials with correlated outcomes. Each chapter is self-contained so readers can explore topics relevant to their research projects without having to refer to other chapters.

Original languageEnglish (US)
PublisherCRC Press
Number of pages235
ISBN (Electronic)9781466556270
ISBN (Print)9781466556263
DOIs
StatePublished - Jan 1 2014

Fingerprint

Sample Size Calculation
Sample Size
Research
Sample Size Determination
Resources
Repeated Measurements
Longitudinal Study
Randomisation
Parameter Design
Missing Data
Random Allocation
Clustering
Cluster Analysis
Longitudinal Studies
Epidemiologic Studies
Requirements
Research Personnel

ASJC Scopus subject areas

  • Mathematics(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Sample size calculations for clustered and longitudinal outcomes in clinical research. / Ahn, Chul; Heo, Moonseong; Zhang, Song.

CRC Press, 2014. 235 p.

Research output: Book/ReportBook

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