Salt intake and renal hemodynamics in immature and mature dahl salt-sensitive (DS/JR) and salt-resistant (DR/JR) rats

Jaling Hua, Frederick J. Kaskel, Charles J. Juno, Leon C. Moore, James A. McCaughran

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9 Scopus citations


To determine if abnormalities in the maturation of renal function in Dahl salt-sensitive rats are associated with the development of hypertension, studies were performed in anesthetized 3 week old salt-sensitive (DS/JR) and salt-resistant (DR/JR) rats whose mothers were maintained on 0.15% (low-salt) during gestation and either 0.15% or 2.0% (high-salt) NaCl diets after parturition. Mature DS/JR and DR/JR rats were maintained on either 0.15% or 2.0% NaCl diets after weaning and studied at 8 to 9 weeks of age. High-salt diet raised blood pressure (BP) and reduced glomerular filtration rate (GFR) and renal blood flow (RBF) in mature DS/JR rats, but had no effect on BP, GFR and RBF in mature DR/JR rats. In immature DS/JR and DR/JR animals, high-salt intake resulted in poor growth with reductions in GFR and RBF in the DS/JR group. The response to acute volume expansion, (5% body weight physiologic saline infusion) differed among the groups. Mature rats all vasodilated while immature high-salt DS/JR did not, and immature low-salt DS/JR vasoconstricted. These studies demonstrated that both mature and immature DS/JR rats evidence abnormal responses to acute and chronic salt loading. Early exposure to high-salt intake affects the maturation of renal function in the DS/JR group. An enhanced vascular sensitivity to sodium is present at critical periods of postnatal development in DS/JR rats. Am J Hyper-tens 1990;3:268-273.

Original languageEnglish (US)
Pages (from-to)268-273
Number of pages6
JournalAmerican journal of hypertension
Issue number4
StatePublished - Apr 1990



  • Blood pressure
  • Dahl rat
  • Growth and maturation of renal function
  • Sodium loading

ASJC Scopus subject areas

  • Internal Medicine

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