S100 proteins as therapeutic targets

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


The human genome codes for 21 S100 protein family members, which exhibit cell- and tissue-specific expression patterns. Despite sharing a high degree of sequence and structural similarity, the S100 proteins bind a diverse range of protein targets and contribute to a broad array of intracellular and extracellular functions. Consequently, the S100 proteins regulate multiple cellular processes such as proliferation, migration and/or invasion, and differentiation, and play important roles in a variety of cancers, autoimmune diseases, and chronic inflammatory disorders. This review focuses on the development of S100 neutralizing antibodies and small molecule inhibitors and their potential therapeutic use in controlling disease progression and severity.

Original languageEnglish (US)
Pages (from-to)1617-1629
Number of pages13
JournalBiophysical Reviews
Issue number6
StatePublished - Dec 1 2018


  • Calcium binding
  • Neutralizing antibody
  • S100 protein
  • Small molecule inhibitor

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology

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