rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease

Zohreh Tatari-Calderone, Caterina P. Minniti, Tonya Kratovil, Milica Stojakovic, Alison Vollmer, Igor Barjaktarevic, Ed Zhang, Albert Hoang, Naomi L C Luban, Stanislav Vukmanovic

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Patients with sickle cell disease (SCD) who receive red blood cell (RBC) transfusions have a higher rate of anti-RBC (allo and auto) antibody development than other transfused subjects. We hypothesized that an incidence and/or kinetics of RBC-specific antibody formation in SCD patients is influenced by a linked inheritance of the hemoglobin beta S (HbβS) allele and a polymorphism rs660C/T in the neighboring Ro52 gene. We found that 75% of C/T heterozygous and only 30.8% of T/T homozygous patients that developed antibodies were first transfused before the age of five. In addition, there was a significant inverse correlation between time of exposure to antigen or number of transfusions received and the age when T/T patients received first transfusion, indicating progressive development of competence of their immune system. In contrast, this correlation was not observed in patients with C/T genotype. Finally, increased expression of Ro52 was associated with the presence of the T/T genotype. These results suggest that rs660 polymorphism is a marker of efficiency of tolerance induction in early childhood and immune competence development to RBC antigens in SCD patients of pre-teen/teen age.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalMolecular Immunology
Volume47
Issue number1
DOIs
StatePublished - Nov 2009
Externally publishedYes

Fingerprint

Sickle Cell Anemia
Erythrocytes
Mental Competency
Genotype
Sickle Hemoglobin
Antigens
Erythrocyte Transfusion
Antibodies
Antibody Formation
Immune System
Alleles
Incidence
Genes

Keywords

  • Antibodies
  • Gene polymorphisms
  • Red blood cell transfusion
  • Sickle cell disease

ASJC Scopus subject areas

  • Molecular Biology
  • Immunology

Cite this

rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. / Tatari-Calderone, Zohreh; Minniti, Caterina P.; Kratovil, Tonya; Stojakovic, Milica; Vollmer, Alison; Barjaktarevic, Igor; Zhang, Ed; Hoang, Albert; Luban, Naomi L C; Vukmanovic, Stanislav.

In: Molecular Immunology, Vol. 47, No. 1, 11.2009, p. 64-70.

Research output: Contribution to journalReview article

Tatari-Calderone, Z, Minniti, CP, Kratovil, T, Stojakovic, M, Vollmer, A, Barjaktarevic, I, Zhang, E, Hoang, A, Luban, NLC & Vukmanovic, S 2009, 'rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease', Molecular Immunology, vol. 47, no. 1, pp. 64-70. https://doi.org/10.1016/j.molimm.2008.12.027
Tatari-Calderone, Zohreh ; Minniti, Caterina P. ; Kratovil, Tonya ; Stojakovic, Milica ; Vollmer, Alison ; Barjaktarevic, Igor ; Zhang, Ed ; Hoang, Albert ; Luban, Naomi L C ; Vukmanovic, Stanislav. / rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease. In: Molecular Immunology. 2009 ; Vol. 47, No. 1. pp. 64-70.
@article{18ba0691cba0410b8dc5e88a4c8d5d6c,
title = "rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease",
abstract = "Patients with sickle cell disease (SCD) who receive red blood cell (RBC) transfusions have a higher rate of anti-RBC (allo and auto) antibody development than other transfused subjects. We hypothesized that an incidence and/or kinetics of RBC-specific antibody formation in SCD patients is influenced by a linked inheritance of the hemoglobin beta S (HbβS) allele and a polymorphism rs660C/T in the neighboring Ro52 gene. We found that 75{\%} of C/T heterozygous and only 30.8{\%} of T/T homozygous patients that developed antibodies were first transfused before the age of five. In addition, there was a significant inverse correlation between time of exposure to antigen or number of transfusions received and the age when T/T patients received first transfusion, indicating progressive development of competence of their immune system. In contrast, this correlation was not observed in patients with C/T genotype. Finally, increased expression of Ro52 was associated with the presence of the T/T genotype. These results suggest that rs660 polymorphism is a marker of efficiency of tolerance induction in early childhood and immune competence development to RBC antigens in SCD patients of pre-teen/teen age.",
keywords = "Antibodies, Gene polymorphisms, Red blood cell transfusion, Sickle cell disease",
author = "Zohreh Tatari-Calderone and Minniti, {Caterina P.} and Tonya Kratovil and Milica Stojakovic and Alison Vollmer and Igor Barjaktarevic and Ed Zhang and Albert Hoang and Luban, {Naomi L C} and Stanislav Vukmanovic",
year = "2009",
month = "11",
doi = "10.1016/j.molimm.2008.12.027",
language = "English (US)",
volume = "47",
pages = "64--70",
journal = "Molecular Immunology",
issn = "0161-5890",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - rs660 polymorphism in Ro52 (SSA1; TRIM 21) is a marker for age-dependent tolerance induction and efficiency of alloimmunization in sickle cell disease

AU - Tatari-Calderone, Zohreh

AU - Minniti, Caterina P.

AU - Kratovil, Tonya

AU - Stojakovic, Milica

AU - Vollmer, Alison

AU - Barjaktarevic, Igor

AU - Zhang, Ed

AU - Hoang, Albert

AU - Luban, Naomi L C

AU - Vukmanovic, Stanislav

PY - 2009/11

Y1 - 2009/11

N2 - Patients with sickle cell disease (SCD) who receive red blood cell (RBC) transfusions have a higher rate of anti-RBC (allo and auto) antibody development than other transfused subjects. We hypothesized that an incidence and/or kinetics of RBC-specific antibody formation in SCD patients is influenced by a linked inheritance of the hemoglobin beta S (HbβS) allele and a polymorphism rs660C/T in the neighboring Ro52 gene. We found that 75% of C/T heterozygous and only 30.8% of T/T homozygous patients that developed antibodies were first transfused before the age of five. In addition, there was a significant inverse correlation between time of exposure to antigen or number of transfusions received and the age when T/T patients received first transfusion, indicating progressive development of competence of their immune system. In contrast, this correlation was not observed in patients with C/T genotype. Finally, increased expression of Ro52 was associated with the presence of the T/T genotype. These results suggest that rs660 polymorphism is a marker of efficiency of tolerance induction in early childhood and immune competence development to RBC antigens in SCD patients of pre-teen/teen age.

AB - Patients with sickle cell disease (SCD) who receive red blood cell (RBC) transfusions have a higher rate of anti-RBC (allo and auto) antibody development than other transfused subjects. We hypothesized that an incidence and/or kinetics of RBC-specific antibody formation in SCD patients is influenced by a linked inheritance of the hemoglobin beta S (HbβS) allele and a polymorphism rs660C/T in the neighboring Ro52 gene. We found that 75% of C/T heterozygous and only 30.8% of T/T homozygous patients that developed antibodies were first transfused before the age of five. In addition, there was a significant inverse correlation between time of exposure to antigen or number of transfusions received and the age when T/T patients received first transfusion, indicating progressive development of competence of their immune system. In contrast, this correlation was not observed in patients with C/T genotype. Finally, increased expression of Ro52 was associated with the presence of the T/T genotype. These results suggest that rs660 polymorphism is a marker of efficiency of tolerance induction in early childhood and immune competence development to RBC antigens in SCD patients of pre-teen/teen age.

KW - Antibodies

KW - Gene polymorphisms

KW - Red blood cell transfusion

KW - Sickle cell disease

UR - http://www.scopus.com/inward/record.url?scp=70350618088&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350618088&partnerID=8YFLogxK

U2 - 10.1016/j.molimm.2008.12.027

DO - 10.1016/j.molimm.2008.12.027

M3 - Review article

C2 - 19201475

AN - SCOPUS:70350618088

VL - 47

SP - 64

EP - 70

JO - Molecular Immunology

JF - Molecular Immunology

SN - 0161-5890

IS - 1

ER -