Roles of hippocampal subfields in verbal and visual episodic memory

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Abstract

Introduction Selective hippocampal (HC) subfield atrophy has been reported in older adults with mild cognitive impairment and Alzheimer's disease. The goal of this study was to investigate the associations between the volume of hippocampal subfields and visual and verbal episodic memory in cognitively normal older adults. Methods This study was conducted on a subset of 133 participants from the Einstein Aging Study (EAS), a community-based study of non-demented older adults systematically recruited from the Bronx, N.Y. All participants completed comprehensive EAS neuropsychological assessment. Visual episodic memory was assessed using the Complex Figure Delayed Recall subtest from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Verbal episodic memory was assessed using Delayed Recall from the Free and Cued Selective Reminding Test (FCSRT). All participants underwent 3T MRI brain scanning with subsequent automatic measurement of the hemispheric hippocampal subfield volumes (CA1, CA2-CA3, CA4-dente gyrus, presubiculum, and subiculum). We used linear regressions to model the association between hippocampal subfield volumes and visual and verbal episodic memory tests while adjusting for age, sex, education, and total intracranial volume. Results Participants had a mean age of 78.9 (SD = 5.1) and 60.2% were female. Total hippocampal volume was associated with Complex Figure Delayed Recall (β = 0.31, p = 0.001) and FCSRT Delayed Recall (β = 0.27, p = 0.007); subiculum volume was associated with Complex Figure Delayed Recall (β = 0.27, p = 0.002) and FCSRT Delayed Recall (β = 0.24, p = 0.010); CA1 was associated with Complex Figure Delayed Recall (β = 0.26, p < 0.002) and FCSRT Delayed Recall (β = 0.20, p = 0.025). Conclusions Our findings confirm previous research on the specific roles of CA1 and subiculum in episodic memory. Our results suggest that hippocampal subfields have sensitive roles in the process of visual and verbal episodic memory.

Original languageEnglish (US)
Pages (from-to)157-162
Number of pages6
JournalBehavioural Brain Research
Volume317
DOIs
StatePublished - Jan 15 2017

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Episodic Memory
Hippocampus
Parahippocampal Gyrus
Sex Education
Atrophy
Linear Models
Alzheimer Disease
Brain
Research

Keywords

  • CA1
  • Hippocampal subfields
  • Older adults
  • Subiculum
  • Verbal episodic memory
  • Visual episodic memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

@article{f8a0d2e7c7ea4508961ac9af12f56b8e,
title = "Roles of hippocampal subfields in verbal and visual episodic memory",
abstract = "Introduction Selective hippocampal (HC) subfield atrophy has been reported in older adults with mild cognitive impairment and Alzheimer's disease. The goal of this study was to investigate the associations between the volume of hippocampal subfields and visual and verbal episodic memory in cognitively normal older adults. Methods This study was conducted on a subset of 133 participants from the Einstein Aging Study (EAS), a community-based study of non-demented older adults systematically recruited from the Bronx, N.Y. All participants completed comprehensive EAS neuropsychological assessment. Visual episodic memory was assessed using the Complex Figure Delayed Recall subtest from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Verbal episodic memory was assessed using Delayed Recall from the Free and Cued Selective Reminding Test (FCSRT). All participants underwent 3T MRI brain scanning with subsequent automatic measurement of the hemispheric hippocampal subfield volumes (CA1, CA2-CA3, CA4-dente gyrus, presubiculum, and subiculum). We used linear regressions to model the association between hippocampal subfield volumes and visual and verbal episodic memory tests while adjusting for age, sex, education, and total intracranial volume. Results Participants had a mean age of 78.9 (SD = 5.1) and 60.2{\%} were female. Total hippocampal volume was associated with Complex Figure Delayed Recall (β = 0.31, p = 0.001) and FCSRT Delayed Recall (β = 0.27, p = 0.007); subiculum volume was associated with Complex Figure Delayed Recall (β = 0.27, p = 0.002) and FCSRT Delayed Recall (β = 0.24, p = 0.010); CA1 was associated with Complex Figure Delayed Recall (β = 0.26, p < 0.002) and FCSRT Delayed Recall (β = 0.20, p = 0.025). Conclusions Our findings confirm previous research on the specific roles of CA1 and subiculum in episodic memory. Our results suggest that hippocampal subfields have sensitive roles in the process of visual and verbal episodic memory.",
keywords = "CA1, Hippocampal subfields, Older adults, Subiculum, Verbal episodic memory, Visual episodic memory",
author = "Zammit, {Andrea R.} and Ali Ezzati and Zimmerman, {Molly E.} and Lipton, {Richard B.} and Lipton, {Michael L.} and Katz, {Mindy Joy}",
year = "2017",
month = "1",
day = "15",
doi = "10.1016/j.bbr.2016.09.038",
language = "English (US)",
volume = "317",
pages = "157--162",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

TY - JOUR

T1 - Roles of hippocampal subfields in verbal and visual episodic memory

AU - Zammit, Andrea R.

AU - Ezzati, Ali

AU - Zimmerman, Molly E.

AU - Lipton, Richard B.

AU - Lipton, Michael L.

AU - Katz, Mindy Joy

PY - 2017/1/15

Y1 - 2017/1/15

N2 - Introduction Selective hippocampal (HC) subfield atrophy has been reported in older adults with mild cognitive impairment and Alzheimer's disease. The goal of this study was to investigate the associations between the volume of hippocampal subfields and visual and verbal episodic memory in cognitively normal older adults. Methods This study was conducted on a subset of 133 participants from the Einstein Aging Study (EAS), a community-based study of non-demented older adults systematically recruited from the Bronx, N.Y. All participants completed comprehensive EAS neuropsychological assessment. Visual episodic memory was assessed using the Complex Figure Delayed Recall subtest from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Verbal episodic memory was assessed using Delayed Recall from the Free and Cued Selective Reminding Test (FCSRT). All participants underwent 3T MRI brain scanning with subsequent automatic measurement of the hemispheric hippocampal subfield volumes (CA1, CA2-CA3, CA4-dente gyrus, presubiculum, and subiculum). We used linear regressions to model the association between hippocampal subfield volumes and visual and verbal episodic memory tests while adjusting for age, sex, education, and total intracranial volume. Results Participants had a mean age of 78.9 (SD = 5.1) and 60.2% were female. Total hippocampal volume was associated with Complex Figure Delayed Recall (β = 0.31, p = 0.001) and FCSRT Delayed Recall (β = 0.27, p = 0.007); subiculum volume was associated with Complex Figure Delayed Recall (β = 0.27, p = 0.002) and FCSRT Delayed Recall (β = 0.24, p = 0.010); CA1 was associated with Complex Figure Delayed Recall (β = 0.26, p < 0.002) and FCSRT Delayed Recall (β = 0.20, p = 0.025). Conclusions Our findings confirm previous research on the specific roles of CA1 and subiculum in episodic memory. Our results suggest that hippocampal subfields have sensitive roles in the process of visual and verbal episodic memory.

AB - Introduction Selective hippocampal (HC) subfield atrophy has been reported in older adults with mild cognitive impairment and Alzheimer's disease. The goal of this study was to investigate the associations between the volume of hippocampal subfields and visual and verbal episodic memory in cognitively normal older adults. Methods This study was conducted on a subset of 133 participants from the Einstein Aging Study (EAS), a community-based study of non-demented older adults systematically recruited from the Bronx, N.Y. All participants completed comprehensive EAS neuropsychological assessment. Visual episodic memory was assessed using the Complex Figure Delayed Recall subtest from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Verbal episodic memory was assessed using Delayed Recall from the Free and Cued Selective Reminding Test (FCSRT). All participants underwent 3T MRI brain scanning with subsequent automatic measurement of the hemispheric hippocampal subfield volumes (CA1, CA2-CA3, CA4-dente gyrus, presubiculum, and subiculum). We used linear regressions to model the association between hippocampal subfield volumes and visual and verbal episodic memory tests while adjusting for age, sex, education, and total intracranial volume. Results Participants had a mean age of 78.9 (SD = 5.1) and 60.2% were female. Total hippocampal volume was associated with Complex Figure Delayed Recall (β = 0.31, p = 0.001) and FCSRT Delayed Recall (β = 0.27, p = 0.007); subiculum volume was associated with Complex Figure Delayed Recall (β = 0.27, p = 0.002) and FCSRT Delayed Recall (β = 0.24, p = 0.010); CA1 was associated with Complex Figure Delayed Recall (β = 0.26, p < 0.002) and FCSRT Delayed Recall (β = 0.20, p = 0.025). Conclusions Our findings confirm previous research on the specific roles of CA1 and subiculum in episodic memory. Our results suggest that hippocampal subfields have sensitive roles in the process of visual and verbal episodic memory.

KW - CA1

KW - Hippocampal subfields

KW - Older adults

KW - Subiculum

KW - Verbal episodic memory

KW - Visual episodic memory

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U2 - 10.1016/j.bbr.2016.09.038

DO - 10.1016/j.bbr.2016.09.038

M3 - Article

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EP - 162

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

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