Role of vasoactive mediators in the pathogenesis of Chagas' disease

Shankar Mukherjee, Huan Huang, Louis M. Weiss, Sylvia Costa, Julio Scharfstein, Herbert B. Tanowitz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

This review focuses on the vascular pathogenesis of Chagas' disease, the cardiomyopathy caused by infection with the parasitic protozoa Trypanosoma cruzi. Recent studies strongly suggests that T. cruzi infection is linked to functional changes in the activity of two potent vasoative peptidergic mediators, endothelin-1, a vasoconstrictor, and kinins, a group of vasodilator and pro-inflammatory peptides related to bradykinin. Understanding the molecular mechanisms underlying disturbances of vascular homoeostasis? induced by T. cruzi may provide opportunities for therapeutic intervention and amelioration of heart pathology.

Original languageEnglish (US)
JournalFrontiers in Bioscience
Volume8
StatePublished - 2003

Fingerprint

Protozoa
Kinins
Chagas Disease
Trypanosoma cruzi
Bradykinin
Vasoconstrictor Agents
Endothelin-1
Pathology
Vasodilator Agents
Peptides
Blood Vessels
Chagas Cardiomyopathy
Parasitic Diseases
Homeostasis
Infection
Therapeutics

Keywords

  • Bradykinin
  • Chagas' disease
  • Endothelin
  • Kinins
  • Review
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Role of vasoactive mediators in the pathogenesis of Chagas' disease. / Mukherjee, Shankar; Huang, Huan; Weiss, Louis M.; Costa, Sylvia; Scharfstein, Julio; Tanowitz, Herbert B.

In: Frontiers in Bioscience, Vol. 8, 2003.

Research output: Contribution to journalArticle

Mukherjee, Shankar ; Huang, Huan ; Weiss, Louis M. ; Costa, Sylvia ; Scharfstein, Julio ; Tanowitz, Herbert B. / Role of vasoactive mediators in the pathogenesis of Chagas' disease. In: Frontiers in Bioscience. 2003 ; Vol. 8.
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