TY - JOUR
T1 - Role of nuclear medicine in neuroHIV
T2 - PET, SPECT, and beyond
AU - Sathekge, Mike
AU - McFarren, Alicia
AU - Dadachova, Ekaterina
PY - 2014/8
Y1 - 2014/8
N2 - HIV-associated neurocognitive disorders (HAND) remain among the most common clinical disorders encountered in people infected with HIV despite widespread use of antiretroviral therapy. There is an enormous need for further evaluation and early diagnosis of HAND. The variety of PET agents such as FDG, 11C-PiB and [11C]-R-PK11195 as well as SPECT agents 99Tc-HMPAO, 123I-FP-CIT and 123I-IBZM have been investigated for the diagnosis of HAND, for distinguishing between demented and nondemented HIV patients, for differentiation between HAND and nonHIV related dementia, as well as for assessing the influence of coinfection with the other viral pathogens on the brain functionality. In spite of some interesting results, none of these tracers have been specifically created for HAND and none can be recommended for HAND diagnosis. Specialized tracers need to be developed for better diagnosis and management of HAND. The potential role of therapeutic nuclear medicine as part of the curative strategies for HIV is also discussed.
AB - HIV-associated neurocognitive disorders (HAND) remain among the most common clinical disorders encountered in people infected with HIV despite widespread use of antiretroviral therapy. There is an enormous need for further evaluation and early diagnosis of HAND. The variety of PET agents such as FDG, 11C-PiB and [11C]-R-PK11195 as well as SPECT agents 99Tc-HMPAO, 123I-FP-CIT and 123I-IBZM have been investigated for the diagnosis of HAND, for distinguishing between demented and nondemented HIV patients, for differentiation between HAND and nonHIV related dementia, as well as for assessing the influence of coinfection with the other viral pathogens on the brain functionality. In spite of some interesting results, none of these tracers have been specifically created for HAND and none can be recommended for HAND diagnosis. Specialized tracers need to be developed for better diagnosis and management of HAND. The potential role of therapeutic nuclear medicine as part of the curative strategies for HIV is also discussed.
KW - PET
KW - SPECT
KW - neuroHIV
KW - radioimmunotherapy
UR - http://www.scopus.com/inward/record.url?scp=84903788127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903788127&partnerID=8YFLogxK
U2 - 10.1097/MNM.0000000000000139
DO - 10.1097/MNM.0000000000000139
M3 - Review article
C2 - 24781008
AN - SCOPUS:84903788127
SN - 0143-3636
VL - 35
SP - 792
EP - 796
JO - Nuclear Medicine Communications
JF - Nuclear Medicine Communications
IS - 8
ER -
